Oncology, Biotechnology & Bioengineering, Hematology, Surgery, Cytology - Stem Cells

Stem Cell Transplantation for Hematologic Malignancies

Name: Stem Cell Transplantation for Hematologic Malignancies
Author: Robert J. Soiffer
ISBN: 9781588291806

by Robert J. Soiffer

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Overview

Over the past several years, fundamental notions about transplantation have changed to such a degree that even the once familiar term, bone marrow transplant, is becoming increasingly outdated. In Stem Cell Transplantation for Hematologic Malignancies, leading investigators and physicians/clinicians comprehensively survey the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic graft-vs-host disease (VGHD), delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation. Also discussed are the role of donor lymphocyte infusions in the treatment and prevention of relapse after stem cell transplantation and their influence on the development of nonmyeloablative transplantation. Comprehensive and state-of-the-art, Stem Cell Transplantation for Hematologic Malignancies outlines the many exciting advances that are working toward realization today while fully explaining the process of stem cell transplantation for malignant disease.

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Editorials

From The Critics

Reviewer: Jane N. Winter, MD(Northwestern University Feinberg School of Medicine)
Description: In this collection, the editor has assembled a comprehensive statement on the state-of-the-art in hematopoietic stem cell transplantation for the hematologic malignancies. Three separate sections focus on: transplant for specific malignant diseases including acute and chronic leukemia, myelodysplasia, the lymphomas, multiple myeloma, and breast cancer; complications of transplantation including acute and chronic graft-vs.-host disease; and graft-related issues including the various sources, graft engineering and graft-vs.-tumor effect.
Purpose: It is the editor's intention that this book provide the reader with a vision of current knowledge and practices as well as future directions in the field. Given the many different approaches to applying the newer concepts in transplantation, it is helpful to have a synthesis such as this one to serve as a guide to the tremendous volume of information available. Readers will find the book useful in navigating the ever-changing field of transplantation.
Audience: The book is targeted to students, physicians, and other healthcare professionals with an interest in hematopoietic stem cell transplant. It should prove accessible and helpful to all of these groups. Both the uninitiated and the expert will find something of interest here.
Features: Current transplant approaches to the individual hematologic malignancies are discussed and the literature critiqued. The diverse complications of transplantation are discussed in considerable detail; the authors clearly define the underlying pathophysiology as well as state-of-the-art treatment approaches. Chapters on the new field of alternative graft sources is one of the book's best features and include unrelated, haploidentical and umbilical cord transplantation. Including transplantation for breast cancer in this book on the hematologic malignancies is confusing, leading the reader to expect chapters on other solid tumors.
Assessment: This is a high-quality publication that is easy to read and not as overwhelming as the larger, more comprehensive transplant books. It is full of helpful information and references. Although it is as up-to-date as a traditional book can be, it is not as current as an online publication. It will serve students, trainees, and others interested in transplantation well.

3 Stars from Doody