Physiology, Endocrinology & Metabolism, Physiology - Stimuli & Behavior, Physiology - General & Miscellaneous, Cytology - General & Miscellaneous, Biochemistry - Proteins - Specific Proteins

Stress-Inducible Cellular Responses

Name: Stress-Inducible Cellular Responses
Author: U. Feige... [et al.]
ISBN: 9780817652050

by U. Feige... [et al.]

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Overview

This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimental approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins.

The book contains black-and-white illustrations.

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Editorials

From The Critics

Reviewer: Juergen Mollenhauer, PhD, DSc(Rush Medical College of Rush University)
Description: Do cells sense deadly threats? The answer from research in cellular stress responses is yes. From photons to pharmakons, these environmental stresses are dealt with by a set of proteins inside a cell: the "heat shock" or "stress" proteins. In an assembly of excellent contributions from outstanding researchers, this book compiles the recent knowledge on a distinct cellular machinery involved in the central tasks of protein folding and intracellular transport. This ranges from the regulation of stress-inducible genes to protein folding to regulation of the immune system, thermotolerance, and handling of infectious agents.
Purpose: According to its editors, the book "aims to offer a textbook-like overview of the field" and is directed to a broad range of researchers in biomedicine. Considering the central role of stress proteins in the normal and "emergency" metabolism and the current knowledge in the field, this book was overdue. It is fortunate that its many international contributors and editors are exceptionally skilled scientists. This is a "must" in a research area combining so many diverse aspects from cellular and molecular biochemistry to pharmacology and clinical therapy.
Audience: The book is written for researchers in these fields but not necessarily for the heat shock community. It requires a broad knowledge of biomedicine to appreciate all the details discussed in the individual contributions, but it also allows one to "graze" on the surface, as it should be with a good textbook.
Features: The quality of the figures is in some contrast to the exceptionally well written text: the limited number of graphical presentations and photographs does not support the reader's imagination and understanding to the extent the book deserves it.
Assessment: This contribution is a milestone in the research of the protein folding and transport apparatus in a cell's good and bad times.

Juergen Mollenhauer

Do cells sense deadly threats? The answer from research in cellular stress responses is yes. From photons to pharmakons, these environmental stresses are dealt with by a set of proteins inside a cell: the "heat shock" or "stress" proteins. In an assembly of excellent contributions from outstanding researchers, this book compiles the recent knowledge on a distinct cellular machinery involved in the central tasks of protein folding and intracellular transport. This ranges from the regulation of stress-inducible genes to protein folding to regulation of the immune system, thermotolerance, and handling of infectious agents. According to its editors, the book "aims to offer a textbook-like overview of the field" and is directed to a broad range of researchers in biomedicine. Considering the central role of stress proteins in the normal and "emergency" metabolism and the current knowledge in the field, this book was overdue. It is fortunate that its many international contributors and editors are exceptionally skilled scientists. This is a "must" in a research area combining so many diverse aspects from cellular and molecular biochemistry to pharmacology and clinical therapy. The book is written for researchers in these fields but not necessarily for the heat shock community. It requires a broad knowledge of biomedicine to appreciate all the details discussed in the individual contributions, but it also allows one to "graze" on the surface, as it should be with a good textbook. The quality of the figures is in some contrast to the exceptionally well written text: the limited number of graphical presentations and photographs does not support the reader's imagination and understandingto the extent the book deserves it. This contribution is a milestone in the research of the protein folding and transport apparatus in a cell's good and bad times.

4 Stars! from Doody