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Overview
Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
Synopsis
Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
Doody Review Services
Reviewer:Celso Agner, MD, MSc(University of Illinois at Chicago College of Medicine)
Description:Since the discovery of central nervous system stem cells, understanding the cell cycle has become crucial for the development of new therapies for conditions such as degenerative diseases. This book is a compilation of the most recent advances in the field.
Purpose:The purpose is to determine the nature of cellular relationships in the central nervous system. Those objectives are met by the authors, who are leading authorities in the field.
Audience:Neurologists, neuroscientists, and neurosurgeons are the main target audience. This is a compilation from many different laboratories, so there is a wide variety of professionals who are, by and large, leading experts in the field.
Features:There is a good fluidity in the division of chapters, which incorporate mechanisms of cell regeneration, prevention of cell death, and mechanisms of cell proliferation in conditions such as glioma. One of the promising areas that has been nicely covered in this book is the neovascularization following extrinsic production of VEGF. This, by itself, may change what is currently thought about chronic stroke therapy in the next 15 to 20 years.
Assessment:This is a good purchase for neurosurgical, neurological, and neuroscience libraries.
Editorials
From The Critics
Reviewer: Celso Agner, MD, MS, MSc(Michigan Neurology Partners)Description: Since the discovery of central nervous system stem cells, understanding the cell cycle has become crucial for the development of new therapies for conditions such as degenerative diseases. This book is a compilation of the most recent advances in the field.
Purpose: The purpose is to determine the nature of cellular relationships in the central nervous system. Those objectives are met by the authors, who are leading authorities in the field.
Audience: Neurologists, neuroscientists, and neurosurgeons are the main target audience. This is a compilation from many different laboratories, so there is a wide variety of professionals who are, by and large, leading experts in the field.
Features: There is a good fluidity in the division of chapters, which incorporate mechanisms of cell regeneration, prevention of cell death, and mechanisms of cell proliferation in conditions such as glioma. One of the promising areas that has been nicely covered in this book is the neovascularization following extrinsic production of VEGF. This, by itself, may change what is currently thought about chronic stroke therapy in the next 15 to 20 years.
Assessment: This is a good purchase for neurosurgical, neurological, and neuroscience libraries.