Overview
Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twentyfive chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer.
Synopsis
Because of the remarkable diversity into which dogs have been bred, they make an ideal model for studying gene plasticity. Along with colleagues from the U. of Pennsylvania School of Veterinary Science and MIT/Harvard U., Ostrander (National Human Genome Research Institute, National Institutes of Health) introduces 25 chapters by experts in fields relating to canine genomics. Topics discussed include dog origins and domestication, morphologic and behavioral variation, and the value of man's best friend as an emerging model for understanding diseases such as cancer and diabetes. Illustrations include a color gallery of recognized dog breeds, phylogenetic trees, and other genetic analyses. Annotation © 2006 Book News, Inc., Portland, OR