Overview
Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities.From the prepublication reviews:
"A delicious masterpiece."
--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases.
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* Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.
* Provides a distinctly immunopharmacological approach to the kinin system.
* Reviews of the role of kinins in disease and inlcudes data from human studies.
* Includes information that is fully up-to-date and comprehensive.
The book contains black-and-white illustrations.
Synopsis
A comprehensive, timely book covering all aspects of the kinin system, from its discovery to the pathophysiology, pharmacology and molecular biology of the mechanisms regulating kinin production and kinin receptors in health and disease, Several chapters contain new information on the gene expression, regulation and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the roles for kinins in pain, angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinitis, myocardial ischemia and other diseases.
Sergei M. Danilov
This book provides complete and up-to-date information about the kallikrein-kinin system and its role in inflammation, sepsis, asthma, adult respiratory distress syndrome, arthritis, and a variety of other pathological conditions. The authors attempted to elucidate the immunopharmacological bias to the kinin system, particularly the role of kinins in inflammation and their protective effects. Indeed, the book can serve as a reference and teaching aid in the pharmacology and biochemistry of the kallikrein-kinin system. This book will be of interest to researchers working in the drug industry and at universities, particularly in the field of inflammation; medical residents and physicians; and practitioners specializing in allergic diseases, inflammation, and cardiovascular medicine. The book is illustrated quite well. Currency and pertinence of the references is very satisfactory. This book was written by leading experts in the biochemistry, immunology, and pharmacology of the kallikrein-kinin system. The book summarizes the current understanding of the pathophysiological significance of the kallikrein-kinin system to many disorders related to inflammation (allergic diseases, pancreatitis, arthritis, etc.) and in cardiovascular diseases. Special attention was devoted to the protective role of endogamous kinins as one of the major factors in the beneficial effects of ACE inhibitors. The book can be recommended to university, medical, and scientific bookstores; health sciences and medical libraries; and researchers and practitioners specializing in inflammatory diseases and in cardiovascular medicine.
Editorials
From The Critics
Reviewer: Sergei M. Danilov, MD, PhD(University of Illinois at Chicago College of Medicine)Description: This book provides complete and up-to-date information about the kallikrein-kinin system and its role in inflammation, sepsis, asthma, adult respiratory distress syndrome, arthritis, and a variety of other pathological conditions.
Purpose: The authors attempted to elucidate the immunopharmacological bias to the kinin system, particularly the role of kinins in inflammation and their protective effects. Indeed, the book can serve as a reference and teaching aid in the pharmacology and biochemistry of the kallikrein-kinin system.
Audience: This book will be of interest to researchers working in the drug industry and at universities, particularly in the field of inflammation; medical residents and physicians; and practitioners specializing in allergic diseases, inflammation, and cardiovascular medicine.
Features: The book is illustrated quite well. Currency and pertinence of the references is very satisfactory.
Assessment: This book was written by leading experts in the biochemistry, immunology, and pharmacology of the kallikrein-kinin system. The book summarizes the current understanding of the pathophysiological significance of the kallikrein-kinin system to many disorders related to inflammation (allergic diseases, pancreatitis, arthritis, etc.) and in cardiovascular diseases. Special attention was devoted to the protective role of endogamous kinins as one of the major factors in the beneficial effects of ACE inhibitors. The book can be recommended to university, medical, and scientific bookstores; health sciences and medical libraries; and researchers and practitioners specializing in inflammatory diseases and in cardiovascular medicine.
Sergei M. Danilov
This book provides complete and up-to-date information about the kallikrein-kinin system and its role in inflammation, sepsis, asthma, adult respiratory distress syndrome, arthritis, and a variety of other pathological conditions. The authors attempted to elucidate the immunopharmacological bias to the kinin system, particularly the role of kinins in inflammation and their protective effects. Indeed, the book can serve as a reference and teaching aid in the pharmacology and biochemistry of the kallikrein-kinin system. This book will be of interest to researchers working in the drug industry and at universities, particularly in the field of inflammation; medical residents and physicians; and practitioners specializing in allergic diseases, inflammation, and cardiovascular medicine. The book is illustrated quite well. Currency and pertinence of the references is very satisfactory. This book was written by leading experts in the biochemistry, immunology, and pharmacology of the kallikrein-kinin system. The book summarizes the current understanding of the pathophysiological significance of the kallikrein-kinin system to many disorders related to inflammation (allergic diseases, pancreatitis, arthritis, etc.) and in cardiovascular diseases. Special attention was devoted to the protective role of endogamous kinins as one of the major factors in the beneficial effects of ACE inhibitors. The book can be recommended to university, medical, and scientific bookstores; health sciences and medical libraries; and researchers and practitioners specializing in inflammatory diseases and in cardiovascular medicine.Booknews
Thirty-three global contributors canvass the ancient on the evolutionary scale kallikrein-kinin system from a immunopharmacological perspective, considering both the positive and nefarious inflammatory mediating effects of such substances as bradykinin, kininase II, and enkephalinase. Papers address the discovery of this system commencing with bradykinin in snake venom 50 years ago, its gene expression, molecular biology, metabolism, the pharmacology of kinin receptors, immunological probes, and its roles in health and various diseases e.g. arthritis, asthma, pancreatitis. Glossary. Annotation c. by Book News, Inc., Portland, Or.3 Stars from Doody