Transport Processes in Pharmaceutical Systems

From The Critics

Reviewer: Donald W. Miller, PhD(University of Nebraska Medical Center)
Description: Transport phenomena, whether they be in the development of suitable drug formulations, the dissolution of drugs from drug matrices, or the absorption, distribution, and elimination of drugs in the body, are recurring themes in pharmaceutical sciences. In this book, the general principles governing transport and their applications in various areas of pharmaceutics are compiled into one source.
Purpose: The purpose is to describe areas of transport phenomena having a direct impact in pharmaceutical science.
Audience: The book is well suited for pharmaceutical scientists of all levels of education and experience.
Features: The text is divided into four sections. In the first section, Chapters 1-5, the basic transport processes and principles are presented. In the second section, Chapters 6-10, biological transport systems involved in the absorption and distribution of drugs are examined. In the third section, Chapters 11-15, drug transport in polymer formulations is discussed. In the final section, Chapters 16 and 17, heat and mass transfer in freeze drying and hygroscopicity are covered.
Assessment: I found the book to be an excellent reference and useful practical guide for understanding transport phenomena in pharmaceutical sciences. The thermodynamic principles that determine mass transport (i.e., Fick's first law, Nernst-Planck equation) are discussed in a straightforward manner and followed with specific applications of mass transport in drug dissolution from various formulations and polymer systems. The biological transport section is heavily weighted towards intestinal absorption issues. However, it should be noted that the biological carriers and transport mechanism discussed have general applications for transport across any cellular barrier. The contributors are experts in their respective fields of pharmaceutical sciences. By describing the various transport processes along with the thermodynamic and kinetic properties involved, the editors present a unified approach to addressing transport issues in pharmaceutics.

Journal of Controlled Release

This book will fill a gap in the field of pharmaceutical sciences....a welcome addition to the field. ...interesting chapters. "...a useful book.

Donald W. Miller

Transport phenomena, whether they be in the development of suitable drug formulations, the dissolution of drugs from drug matrices, or the absorption, distribution, and elimination of drugs in the body, are recurring themes in pharmaceutical sciences. In this book, the general principles governing transport and their applications in various areas of pharmaceutics are compiled into one source. The purpose is to describe areas of transport phenomena having a direct impact in pharmaceutical science. The book is well suited for pharmaceutical scientists of all levels of education and experience. The text is divided into four sections. In the first section, Chapters 1-5, the basic transport processes and principles are presented. In the second section, Chapters 6-10, biological transport systems involved in the absorption and distribution of drugs are examined. In the third section, Chapters 11-15, drug transport in polymer formulations is discussed. In the final section, Chapters 16 and 17, heat and mass transfer in freeze drying and hygroscopicity are covered. I found the book to be an excellent reference and useful practical guide for understanding transport phenomena in pharmaceutical sciences. The thermodynamic principles that determine mass transport (i.e., Fick's first law, Nernst-Planck equation) are discussed in a straightforward manner and followed with specific applications of mass transport in drug dissolution from various formulations and polymer systems. The biological transport section is heavily weighted towards intestinal absorption issues. However, it should be noted that the biological carriers and transport mechanism discussed have general applications fortransport across any cellular barrier. The contributors are experts in their respective fields of pharmaceutical sciences. By describing the various transport processes along with the thermodynamic and kinetic properties involved, the editors present a unified approach to addressing transport issues in pharmaceutics.

Booknews

In this reference, 17 articles explain pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Among other topics, they discuss the crucial relationship between the transport process and thermodynamic factors, the dynamics of diffusion with various interfaces, prodrug design, effects of external stimuli, properties of hydrogels, mass transfer of drugs and pharmacokinetics based on mass balance descriptions. Edited by Amidon (U. of Michigan), Ping I. Lee (Schering-Plough Corp.) and Elizabeth M. Topp (U. of Kansas). Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody