Physiology, Biochemistry - Free Radicals & Antioxidants, Genetics - DNA & RNA, Genetics, Pathology, Pharmacology, Pathophysiology
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Overview
This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area.Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants!
Featuring the research of over 55 experts in the area, Understanding the Process of Aging
- covers the functions of nitric oxide and peroxynitrite in mitochondria
- integrates several views on the role of mitochondria in the development of apoptosis
- gives a quantitative analysis of mutations of mitochondrial DNA during human aging
- highlights mitochondrial free radical production
- introduces new roles of ubiquinone in mitochondrial functions
- offers new antioxidant-based complementary therapeutic strategies
- details aspects of intact cells and whole organisms in health and disease
- and more!
Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.
The book contains black-and-white illustrations.
Editorials
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: A long standing hypothesis regarding aging (however defined) relates to cumulative oxidative damage caused to cells and extracellular matrix components. The focus in this volume is on the possible relationship of mitochondria and their components to this process.
Purpose: The purpose is to provide an examination of a current hypothesis of the role of mitochondria in aging.
Audience: This book is intended for those scientists working on the molecular aspects of aging.
Features: Topics include oxygen radical production, nitric oxide, superoxide, ubiquinone, relationship to apoptosis, and iron. Damage to mitochondrial DNA is also considered. In several of the chapters the editors provide circumstantial but not hard evidence, a common problem in this field. The individual contributions are well prepared and each has a suitable bibliography.
Assessment: Given the nature of the problem and the difficulty in doing molecular studies in this area, this up-to-date recapitulation will be of value to those interested in exploring the yin-yang of oxygen as both necessity and threat.
Eugene A. Davidson
A long standing hypothesis regarding aging (however defined) relates to cumulative oxidative damage caused to cells and extracellular matrix components. The focus in this volume is on the possible relationship of mitochondria and their components to this process. The purpose is to provide an examination of a current hypothesis of the role of mitochondria in aging. This book is intended for those scientists working on the molecular aspects of aging. Topics include oxygen radical production, nitric oxide, superoxide, ubiquinone, relationship to apoptosis, and iron. Damage to mitochondrial DNA is also considered. In several of the chapters the editors provide circumstantial but not hard evidence, a common problem in this field. The individual contributions are well prepared and each has a suitable bibliography. Given the nature of the problem and the difficulty in doing molecular studies in this area, this up-to-date recapitulation will be of value to those interested in exploring the yin-yang of oxygen as both necessity and threat.2 Stars from Doody
Book Details
Published
January 12, 1999
Publisher
New York : Marcel Dekker, c1999.
Pages
384
Format
Hardcover
ISBN
9780824717230