Overview
Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory “course” along with guidance to the literature for more detailed understanding.
The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.
Editorials
American Journal of Pharmaceutical Education
...a valuable reference for toxicologists, pharmacologists, biochemists, physiologists, and other biomedical scientists who need authoritative information on the use of animal models in drug and chemical evaluation and risk assessment for teaching, research, testing, or regulatory purposes. This book should be in the personal libraries of the professionals mentioned above as well as in the libraries of all educational, industrial, commercial, regulatory, and research institutions serving those disciplines...an excellent choice as a supplemental reference text for a course in toxicological methods or research techniques.Indian Journal of Toxicology
...highly recommended.International Journal of Biochemistry
...deals with the toxicology, pathology, and metabolism in all the standard animals with a chapter each of the following: rat, mouse, hamster, guinea pig, rabbit, ferret, dog, non human primates. There are also chapters on alternative species (earthworms, fish, minipigs); model selection and scaling; susceptibility factors; legal regulations; commercial sources of animals. All those who use laboratory animals will find this a useful book to read. Those carrying out drug tests will find it essential reading.Journal of Pharmaceutical Pharmacology
...the book achieves its aim admirably. Clear descriptions with excellent illustrations are given for procedures such as dosing and removal of body fluids for both rat and mouse, followed by an outline of the pathology that may affect the design and interpretation of experiments.American Journal of Pharmaceutical Ed.
...a valuable reference for toxicologists, pharmacologists, biochemists, physiologists, and other biomedical scientists who need authoritative information on the use of animal models in drug and chemical evaluation and risk assessment for teaching, research, testing, or regulatory purposes. This book should be in the personal libraries of the professionals mentioned above as well as in the libraries of all educational, industrial, commercial, regulatory, and research institutions serving those disciplines...an excellent choice as a supplemental reference text for a course in toxicological methods or research techniques.International Journal of Biochemistry
...deals with the toxicology, pathology, and metabolism in all the standard animals with a chapter each of the following: rat, mouse, hamster, guinea pig, rabbit, ferret, dog, non human primates. There are also chapters on alternative species (earthworms, fish, minipigs); model selection and scaling; susceptibility factors; legal regulations; commercial sources of animals. All those who use laboratory animals will find this a useful book to read. Those carrying out drug tests will find it essential reading.JPP
...the book achieves its aim admirably. Clear descriptions with excellent illustrations are given for procedures such as dosing and removal of body fluids for both rat and mouse, followed by an outline of the pathology that may affect the design and interpretation of experiments.—Journal of Pharmaceutical Pharmacology