In Vitro Toxicology

From The Critics

Reviewer: David Chandler, PhD, DABT, CIA (3M)
Description: This book reviews the most recent findings on in vitro testing and the support for these tests.
Purpose: The objectives of this book are to review the in vitro models used in toxicology, evaluate each test's ability to predict results as compared to in vivo findings, regulate acceptance of the models, and provide specific evaluation of end points used in toxicology testing.
Audience: The audiences are experienced toxicologists with an interest in regulatory compliance and testing of materials. They would be interested in animal use reduction and acceptance by regulatory agencies.
Features: This book reviews the various end points used in toxicology and compares the findings from in vivo studies to in vitro models. Each chapter carefully reviews the findings and indicates which of the in vitro tests provide the most accurate assessment of the materials properties. Experts in the field provide an exceptional and thorough evaluation of the materials.
Assessment: This second edition is an excellent review of the current state of in vitro testing and is well written. The authors are known experts in the fields that they have reviewed. The chapters evaluate the in vitro tests and compare them to known in vivo tests, but the most valuable content is the comments on the strength of these tests for prediction as compared to the in vivo counterparts. The text will be very valuable to practicing toxicologists.

Booknews

There now exist a broad range of in vitro models for use in either identifying or understanding most forms of toxicity. The availability of in vitro models spans both the full range of endpoints (irritation, sensitization, lethality, mutagenicity, and developmental toxicity) and the full spectrum of target organ systems (skin, eye, heart, liver, kidney, nervous system, etc.). This volume devotes chapters to each of these specialty areas from a perspective of presenting the principal models and their uses and limitations. Also included are chapters that overview the principles involved in the general selection and use of models, and that address the issues of safety concerns and regulatory acceptance of these methods. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody