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Overview
Apoptosis and the Immune Response
Edited by Christopher D. Gregory
In this timely and important work, an international group of leading investigators takes a close and critical look at programmed cell death and its role in the development, function, and maintenance of the immune system. Along with covering the primary actions of apoptosis, the contributors probe its role in carcinogenesis and HIV-induced pathogenesis. By offering a broad range of views, Apoptosis and the Immune Response presents a current and complete picture of the various aspects and consequences of this phenomenon.
Apoptosis and the Immune Response begins with the theories surrounding apoptosis and then covers its basic mechanisms including the morphologic, biochemical, and genetic features. The book offers authoritative discussions on the role of apoptosis in the deletion of self-reactive lymphocytes, prevention of autoimmunity, termination of the immune response, death of T cells infected by the HIV virus, neoplasia, and the homeostatic regulation of the hematopoietic system.
In particular, this excellent reference critiques such topics as:
* Apoptosis in thymocytes in vivo and in vitro
* Bcl-2/T-cell transgenics
* The role of c-myc
* Fas/APO-1 antigens and their roles
* Transgenic models of B-cell tolerance and autoimmunity
* How apoptosis affects the pathogenesis of AIDS and the implications for therapy
* Triggers for apoptosis and survival
* Recognition of apoptotic cells by phagocytes
* Apoptosis in peritoneal autoreactive CD5+ B cells
* and more
With its diverse expertise and timely, clear-cut insights, Apoptosis and the Immune Response will prove to be an invaluable resource for immunologists, cell and developmental biologists, hematologists, and oncologists—as well as graduate students.
Cover Design: Janice Noto-Helmers
The book contains black-and-white illustrations.
Editorials
From The Critics
Reviewer: Phong T. Le, PhD(Loyola University Medical Center)Description: This book, in its first edition, describes the cellular and molecular events that affect apoptosis in T and B cells. The book covers apoptosis in the normal development of T and B cells as well as apoptosis that occurs in immunological disorders such as AIDS and neoplasia.
Purpose: The purpose is to provide an in-depth review of the apoptotic process as it is related to our current understanding of the development of T and B cells in the normal physiological process and in immunological disorders. The authors, by providing sufficient background information and correlating it with the developing concepts in immunology and apoptosis, have successfully met the book's objectives.
Audience: As indicated by the authors, the book is written at an appropriate level for graduate students in immunology and immunologists. The authors are well known and are respected in their areas of active research.
Features: The physical appearance of the book is quite attractive. Most of the chapters contain simple and comprehensive illustrations. The chapters are well developed with emphasis on the development of our current understanding of the development of T and B cells as it is related to the apoptotic process. Excellent up-to-date references are included; original data are also included in several chapters.
Assessment: This is an excellent book that describes the important functions of apoptosis in the normal development of T and B cells as well as in certain immunological disorders such as AIDS and neoplasia. Written by respected investigators in the field, the book is quite appropriate for graduate students in immunology as well as immunologists. It is useful for students and researchers who need to know the current understanding of the cellular and molecular events that occur in apoptosis of immune cells during normal development, in immune responses, and in diseased states. This book would be a good addition to any medical library.
Phong T. Le
This book, in its first edition, describes the cellular and molecular events that affect apoptosis in T and B cells. The book covers apoptosis in the normal development of T and B cells as well as apoptosis that occurs in immunological disorders such as AIDS and neoplasia. The purpose is to provide an in-depth review of the apoptotic process as it is related to our current understanding of the development of T and B cells in the normal physiological process and in immunological disorders. The authors, by providing sufficient background information and correlating it with the developing concepts in immunology and apoptosis, have successfully met the book's objectives. As indicated by the authors, the book is written at an appropriate level for graduate students in immunology and immunologists. The authors are well known and are respected in their areas of active research. The physical appearance of the book is quite attractive. Most of the chapters contain simple and comprehensive illustrations. The chapters are well developed with emphasis on the development of our current understanding of the development of T and B cells as it is related to the apoptotic process. Excellent up-to-date references are included; original data are also included in several chapters. This is an excellent book that describes the important functions of apoptosis in the normal development of T and B cells as well as in certain immunological disorders such as AIDS and neoplasia. Written by respected investigators in the field, the book is quite appropriate for graduate students in immunology as well as immunologists. It is useful for students and researchers who need to know the current understanding of thecellular and molecular events that occur in apoptosis of immune cells during normal development, in immune responses, and in diseased states. This book would be a good addition to any medical library.Booknews
Examines programmed cell death and its role in the development, function, and maintenance of the normal immune system, and also its role in carcinogenesis and HIV-induced pathogenesis. Reviews the theories, the basic mechanisms, the morphology, the biochemistry, and the genetics of apoptosis; then discusses its role in deleting self-reactive lymphocytes, preventing autoimmunity, terminating the immune response, the death of T cells infected by the HIV virus, neoplasia, and the homeostatic regulation of the hematopoietic system. For researchers and graduate students in the relevant biological and medical sciences. Annotation c. Book News, Inc., Portland, OR (booknews.com)4 Stars! from Doody