T-Cell Autoimmunity and Multiple Sclerosis

From The Critics

Reviewer: Marion C. Cohen, PhD(SUNY Downstate Medical Center)
Description: The is a series of reviews revolving around the common theme of the role of T-cell autoimmunity in the development of multiple sclerosis. It is part of a series of texts on various aspects of neuroscience published by R.G. Landes Company.
Purpose: The rationale behind the topics covered in this book is presumably as stated by the title — to focus on many aspects of T-cell autoimmunity and their roles in the development of multiple sclerosis, since it is well accepted that it is the action of T-cells that ultimately leads to the damage associated with the disease. Since there is no preface, I can only guess at the rationale behind the editor's choices of subjects to be included. Both the human disease and animal models of the disease are discussed, making this a useful book packed with information.
Audience: The book is written for immunologists and should be of particular interest to those who do research on multiple sclerosis. The editor's expertise appears to be in the area of T-cells and T-cell cytokines in autoimmunity. The contributors are all experts in the topics about which they have written.
Features: The material covered in this book is focused on the effect of T-cells on the pathogenesis of multiple sclerosis. Each chapter begins with an overview to lead into the specific area to be discussed. Animal models are included. The book does not contain many tables or figures and none are in color, which would have been helpful in at least one case.
Assessment: Multiple sclerosis is a disease which involves both the neurological and immunological systems. The reviews in this book contain important information about the T-cells and the T-cell-derived cytokines that appear to be important in the development and exacerbation of the disease. The reviews are well written and the reference lists are generally large.

Marion C. Cohen

The is a series of reviews revolving around the common theme of the role of T-cell autoimmunity in the development of multiple sclerosis. It is part of a series of texts on various aspects of neuroscience published by R.G. Landes Company. The rationale behind the topics covered in this book is presumably as stated by the title -- to focus on many aspects of T-cell autoimmunity and their roles in the development of multiple sclerosis, since it is well accepted that it is the action of T-cells that ultimately leads to the damage associated with the disease. Since there is no preface, I can only guess at the rationale behind the editor's choices of subjects to be included. Both the human disease and animal models of the disease are discussed, making this a useful book packed with information. The book is written for immunologists and should be of particular interest to those who do research on multiple sclerosis. The editor's expertise appears to be in the area of T-cells and T-cell cytokines in autoimmunity. The contributors are all experts in the topics about which they have written. The material covered in this book is focused on the effect of T-cells on the pathogenesis of multiple sclerosis. Each chapter begins with an overview to lead into the specific area to be discussed. Animal models are included. The book does not contain many tables or figures and none are in color, which would have been helpful in at least one case. Multiple sclerosis is a disease which involves both the neurological and immunological systems. The reviews in this book contain important information about the T-cells and the T-cell-derived cytokines that appear to be important in the development andexacerbation of the disease. The reviews are well written and the reference lists are generally large.

Booknews

Reports on the latest advances in the field, for new and experienced scientists. Coverage includes the role of T-cells in multiple sclerosis (MS), T-cell autoimmunity and EAE in nonhuman primates, MBP-reactive T-cells in MS, and genetic engineering of brain-specific T-cells for treatment of diseases in the central nervous system. Also discussed are T-cells and cytokines, cytokines in MS and its experimental models, antigen-specific T-cell responses in autoimmune demyelinating disease, and immunopathogenesis of MS. The editor is affiliated with the Kennedy Institute of Rheumatology, UK. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody