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Overview
The book Autoimmune Rheumatic Disease (second edition) is a new fully revised edition of the award winning title. It fills the gap in the literature in that no other book bridges the divide between the clinical characterisation and treatment of autoimmune rheumatic diseases on the one hand and an understanding of laboratory-based research and disease pathogenesis on the other. This second edition is especially important because it describes and explains the advances in molecular biological techniques that have brought about major changes in understanding and also covers the new therapies which have been developed for many autoimmune rheumatic diseases.
The book contains predominantly color illustrations, with some black-and-white illustrations.
Synopsis
The book Autoimmune Rheumatic Disease (second edition) is a new fully revised edition of the award winning title. It fills the gap in the literature in that no other book bridges the divide between the clinical characterisation and treatment of autoimmune rheumatic diseases on the one hand and an understanding of laboratory-based research and disease pathogenesis on the other. This second edition is especially important because it describes and explains the advances in molecular biological techniques that have brought about major changes in understanding and also covers the new therapies which have been developed for many autoimmune rheumatic diseases.
Wayne M. Yokoyama
This is the second edition of a book first published in 1987 that reviews the clinical and scientific aspects of autoimmune rheumatic diseases. "This is an attempt to draw clinicians and basic scientists together by describing clinical aspects of rheumatic diseases, reviews of immunopathology, analysis of animal models, and laboratory tests. These are worthy objectives. However, it is difficult to simplify the complexities of clinical medicine on one hand and basic science on the other to reach basic scientists and clinicians, respectively, without creating simplified and noncohesive lists. "According to the authors, the book is written for clinicians and scientists. The authors are credible but the book has many errors that diminish enthusiasm. Some specific examples: page 13 - Cytotoxic T Cells can be either CD8+ or CD4+, though most are CD8+. The CD8 molecule marks an MHC class I-restricted T cells. Figure 3.1 CD4+ T cells do not present antigen. "All of the major systematic autoimmune clinical syndromes and diseases of rheumatology are covered. The most useful is the discussion of animal models for each disorder. The chapter on immunological tests is well done also. The clinical disorders are well illustrated. The composite illustrations of major clinical manifestations are particularly helpful. The major shortcomings are the numerous errors as noted above. Also, a discussion of inflammation and its mediators would be helpful, since there are new insights into mediators that are involved in inflammation specific to rheumatoid arthritis (RA). Tumor necrosis factor-alpha and cycloxygenase-2 inhibitors are important new drugs for treatment of RA. A broader discussion ofgenetic models would also be helpful in view of the coming age of genomics. "This is an interesting book. The major strength is discussion of animal models of the major rheumatic diseases. Its usefulness is limited by absence of discussion of inflammation and its mediators, TNF and COX-2 in particular, and genetic models of rheumatic diseases.
Editorials
From The Critics
Reviewer: Wayne M. Yokoyama, MD(Washington University Medical Center)Description: This is the second edition of a book first published in 1987 that reviews the clinical and scientific aspects of autoimmune rheumatic diseases.
Purpose: This is an attempt to draw clinicians and basic scientists together by describing clinical aspects of rheumatic diseases, reviews of immunopathology, analysis of animal models, and laboratory tests. These are worthy objectives. However, it is difficult to simplify the complexities of clinical medicine on one hand and basic science on the other to reach basic scientists and clinicians, respectively, without creating simplified and noncohesive lists.
Audience: According to the authors, the book is written for clinicians and scientists. The authors are credible but the book has many errors that diminish enthusiasm. Some specific examples: page 13 - Cytotoxic T Cells can be either CD8+ or CD4+, though most are CD8+. The CD8 molecule marks an MHC class I-restricted T cells. Figure 3.1 CD4+ T cells do not present antigen.
Features: All of the major systematic autoimmune clinical syndromes and diseases of rheumatology are covered. The most useful is the discussion of animal models for each disorder. The chapter on immunological tests is well done also. The clinical disorders are well illustrated. The composite illustrations of major clinical manifestations are particularly helpful. The major shortcomings are the numerous errors as noted above. Also, a discussion of inflammation and its mediators would be helpful, since there are new insights into mediators that are involved in inflammation specific to rheumatoid arthritis (RA). Tumor necrosis factor-alpha and cycloxygenase-2 inhibitors are important new drugs for treatment of RA. A broader discussion of genetic models would also be helpful in view of the coming age of genomics.
Assessment: This is an interesting book. The major strength is discussion of animal models of the major rheumatic diseases. Its usefulness is limited by absence of discussion of inflammation and its mediators, TNF and COX-2 in particular, and genetic models of rheumatic diseases.
Wayne M. Yokoyama
This is the second edition of a book first published in 1987 that reviews the clinical and scientific aspects of autoimmune rheumatic diseases. "This is an attempt to draw clinicians and basic scientists together by describing clinical aspects of rheumatic diseases, reviews of immunopathology, analysis of animal models, and laboratory tests. These are worthy objectives. However, it is difficult to simplify the complexities of clinical medicine on one hand and basic science on the other to reach basic scientists and clinicians, respectively, without creating simplified and noncohesive lists. "According to the authors, the book is written for clinicians and scientists. The authors are credible but the book has many errors that diminish enthusiasm. Some specific examples: page 13 - Cytotoxic T Cells can be either CD8+ or CD4+, though most are CD8+. The CD8 molecule marks an MHC class I-restricted T cells. Figure 3.1 CD4+ T cells do not present antigen. "All of the major systematic autoimmune clinical syndromes and diseases of rheumatology are covered. The most useful is the discussion of animal models for each disorder. The chapter on immunological tests is well done also. The clinical disorders are well illustrated. The composite illustrations of major clinical manifestations are particularly helpful. The major shortcomings are the numerous errors as noted above. Also, a discussion of inflammation and its mediators would be helpful, since there are new insights into mediators that are involved in inflammation specific to rheumatoid arthritis (RA). Tumor necrosis factor-alpha and cycloxygenase-2 inhibitors are important new drugs for treatment of RA. A broader discussion ofgenetic models would also be helpful in view of the coming age of genomics. "This is an interesting book. The major strength is discussion of animal models of the major rheumatic diseases. Its usefulness is limited by absence of discussion of inflammation and its mediators, TNF and COX-2 in particular, and genetic models of rheumatic diseases.2 Stars from Doody