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Synopsis
Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols which aim to apply multiple technologies at different molecular levels in order to surmount the monumental and complex task of transforming the pharmaceutical research and development processes. As a volume in the Methods in Pharmacology and Toxicology™ series, this book offers user-friendly, step-by-step laboratory protocols for readily reproducible experiments.
Comprehensive and state-of-the-art, Biomarker Methods in Drug Discovery and Development is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.
Doody Review Services
Reviewer:Thomas L. Pazdernik, PhD(University of Kansas Medical Center)
Description:In this offering from the Methods in Pharmacology and Toxicology series, expert researchers present a toolbox for those who have an interest in biomarker research to improve drug discovery and development efficiency with an eye towards the future of personalized medicine.
Purpose:The goal is to present biomarker technologies including both those that are well validated and those that hold great promise for future research. This book is intended to be used as a guide and protocol reference for biomarker researchers. The goals are well met by excellent contributions from experts in the field.
Audience:This book is most suited for academicians and pharmaceutical scientists interested in drug discovery and development.
Features:The first chapter addresses the collection of samples from animal and clinical studies in such a way to control and reduce experimental variability. Chapter 2 gives three examples of gene expression-based biomarkers for hepatotoxicity, nephrotoxicity, and general toxicity signatures in blood via the use of microarray platform technologies. Chapters 3 and 4 provide detailed protocols for fluorescent microsphere gene expression platforms and real-time PCR technologies, respectively. Chapter 5 deals with serial analysis of gene expression (SAGE) methodology and bioinformatics approach for SNP analysis. Pyrosequencing and laser capture microdissection (LCM) are covered in chapters 6 and 7. The next six chapters deal with protein biomarker analysis technologies. The last four chapters discuss the use of metabonomics, metabolomics, and lipidomics in biomarker discovery. These chapters provide user-friendly, step-by-step, state-of-the-art protocols for carrying out reproducible biomarker research studies.
Assessment:This book provides detailed description and discussions on multiple biomarker analysis methods that should be extremely useful to pharmaceutical scientists who are involved in research all the way from early drug discovery through clinical trials.