Cellular Respiration and Carcinogenesis
Shireesh P. Apte (Editor), Gregg L. Semenza, Rangaprasad SarangarajanBooks.org participates in affiliate programs including Bookshop.org and the Amazon Services LLC Associates Program. We may earn a commission from qualifying purchases made through links on this page, at no additional cost to you.
Overview
Cellular Respiration and Carcinogenesis presents leading experts in the field as it informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mihondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with, and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation (cellular respiration) to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse to a cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development.
Synopsis
Cellular Respiration and Carcinogenesis presents leading experts in the field as it informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanism or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with, and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation (cellular respiration) to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse to a cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development.
Doody Review Services
Reviewer:Bruce A. Fenderson, PhD(Thomas Jefferson University)
Description:In 1924 Otto Warburg suggested that neoplasia might be caused by impaired oxygen consumption and increased glycolysis. Over the intervening years, the "Warburg Hypothesis" has been supported and extended. However, the biochemical and clinical significance of these research findings remains controversial. Does tumor heterogeneity lead to selection for survival and growth under hypoxic conditions? Does this selection contribute to mitochondrial pathology and defective cell signaling? This concise book critically evaluates these arguments and presents exciting new theories supported by cutting-edge research. It includes 12 chapters on topics ranging from the regulation of glucose metabolism in neoplastic cells to a discussion of how cancer cells escape programmed cell death.
Purpose:According to the editors, the purpose is to "unequivocally address the effects of dysfunction of...cellular respiration mechanisms and pathways on the development of cancer." They hope that this book opens a dialogue on the hypothesis that neoplasia is associated with and significantly attributed to the failure of oxidative phosphorylation. The authors are experts who have thought deeply about the relationship between intermediary metabolism and cell growth.
Audience:The book is written for clinical and basic science researchers across a wide range of life science disciplines including cell biology, biochemistry, physiology, and medical oncology. Students and experts alike will appreciate this thoughtful and stimulating review of the field.
Features:The authors proceed from historical accounts to cutting-edge research. Each chapter includes an abstract, list of keywords, discussion, and extensive list of references. The book includes one color plate and helpful illustrations. The authors critically evaluate the literature.
Assessment:This book captures the excitement of the field. This is the book to have if you are interested in glucose metabolism, oxygen utilization, ATP, mitochondrial function, apoptosis, and cancer. The chapters are filled with fascinating ideas and the authors provide a helpful introduction to the literature, organizing current research findings and helping to elucidate basic mechanisms of cell growth and neoplasia.
Editorials
From The Critics
Reviewer: Bruce A. Fenderson, PhD(Thomas Jefferson University)Description: In 1924 Otto Warburg suggested that neoplasia might be caused by impaired oxygen consumption and increased glycolysis. Over the intervening years, the "Warburg Hypothesis" has been supported and extended. However, the biochemical and clinical significance of these research findings remains controversial. Does tumor heterogeneity lead to selection for survival and growth under hypoxic conditions? Does this selection contribute to mitochondrial pathology and defective cell signaling? This concise book critically evaluates these arguments and presents exciting new theories supported by cutting-edge research. It includes 12 chapters on topics ranging from the regulation of glucose metabolism in neoplastic cells to a discussion of how cancer cells escape programmed cell death.
Purpose: According to the editors, the purpose is to "unequivocally address the effects of dysfunction of...cellular respiration mechanisms and pathways on the development of cancer." They hope that this book opens a dialogue on the hypothesis that neoplasia is associated with and significantly attributed to the failure of oxidative phosphorylation. The authors are experts who have thought deeply about the relationship between intermediary metabolism and cell growth.
Audience: The book is written for clinical and basic science researchers across a wide range of life science disciplines including cell biology, biochemistry, physiology, and medical oncology. Students and experts alike will appreciate this thoughtful and stimulating review of the field.
Features: The authors proceed from historical accounts to cutting-edge research. Each chapter includes an abstract, list of keywords, discussion, and extensive list of references. The book includes one color plate and helpful illustrations. The authors critically evaluate the literature.
Assessment: This book captures the excitement of the field. This is the book to have if you are interested in glucose metabolism, oxygen utilization, ATP, mitochondrial function, apoptosis, and cancer. The chapters are filled with fascinating ideas and the authors provide a helpful introduction to the literature, organizing current research findings and helping to elucidate basic mechanisms of cell growth and neoplasia.