Chiral Chromatography

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included:
* chiral separations involving both gas and liquid chromatography
* descriptions of the apparatus used for both techniques
* detailed discussion on the retention mechanism that results in chiral selectivity
* the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography
* preparative applications for large scale purification of enantiomers
* applications of capillary electrophoresis and capillary electrochromatography.
In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.

Chiral Chromatography Contents An Introduction to Chiral Chromatography Mechanism of Solute Retention Molecular Interactions The Basic Gas Chromatograph Gas Chromatography Chiral Stationary Phases and Columns Chiral Gas Chromatography Applications The Basic Liquid Chromatograph Liquid Chromatography Chiral Stationary Phases The Preparation of LC Chiral Phases and Columns Column Temperature and Mobile Phase Composition Chiral Liquid Chromatography Applications Preparative Chiral Chromatography Chiral Separations by Capillary Electrophoresis and Capillary Electrochromatography An Experimental Approach to Chiral Chromatography Separation Science Series Series Editors R. P. W. Scott, C. F. Simpson and E. D. Katz Separation Science Series Series Editors R.P.W. Scott, C.F. Simpson and E.D. Katz Chiral Chromatography Thomas E. Beesley and Raymond P.W. Scott Tandem Techniques Raymond P.W. Scott High Performance Liquid Chromatography Principles and Methods in Biotechnology Edited by Elena Katz Capillary Gas Chromatography David W. Grant Silica Gel and Bonded Phases Their Production, Properties and Use in LC Raymond P.W. Scott Liquid Chromatography Column Theory Raymond P.W. Scott The Analysis of Drugs of Abuse Edited by Terry A. Gough Quantitative Analysis Using Chromatographic Techniques Edited by Elena D. Katz

Booknews

A practical reference for analysts in chemical, pharmaceutical, and clinical laboratories to the technique of separating enantiomers with the help of chromatography. Describes chiral separations involving both gas and liquid chromatography and the apparatus used for both, the retention mechanism that results in chiral selectivity, the structure and synthesis of a wide range of chirally active stationary phases used in both techniques, preparative applications for large-scale purifications of enantiomers, and applications of capillary eletrophoresis and capillary electrochromatography. Chiral separation is most often used in pharmaceuticals at present, and many examples of commercially or physiologically interesting chiral mixtures are presented, along with a discussion of the mechanism of selectivity in each case. Annotation c. by Book News, Inc., Portland, Or.

Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P.W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK