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Overview
Well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiologic or pathologic responses among inbred mouse strains, thus facilitating more rapid genetic discovery. The focus is on the haplotype-based computational genetic analysis method and its application to inbred mouse strains. Reviewing murine models of asthma, lung disease, osteoporosis, and substance abuse, the contributors provide an overview of available mouse models, what has been learned from them, and which new models must be developed to advance our understanding of these diseases. They also describe how genetic analysis of human populations has yielded information on the genetic basis for susceptibility to asthma and other inflammatory diseases.
Synopsis
Peltz, a genetics and genomics researcher, presents reviews and assessments of both currently available and emerging tools for the rapid identification of the genetic basis for susceptibility to disease. A new computational approach, the haplotype-based computational genetic analysis method, is introduced, which allows researchers to identify the genetic basis for differences in physiological or pathological responses among inbred mouse strains. There is also material on genetic analysis of human populations. The book is for investigators working in genetics and the biology of disease processes. Annotation ©2005 Book News, Inc., Portland, OR