Overview
Featuring more than 10,000 references and a text lavishly complemented by over 700 illustrations, DNA Repair and Mutagenesis, 2nd Edition, is a timely update to the original edition published in 1995. The addition of three new authors, including an expert in the field of structural biology, ensures a comprehensive review of the most current research in diverse subject areas. An ideal textbook for advanced undergraduate and graduate students, the book is also an essential resource for all scientists researching cellular responses to DNA damage.The book contains both black-and-white and color illustrations.
Synopsis
Friedberg (pathology, University of Texas Southwestern Medical Center) reviews the most current research in the field in this resource for advanced undergraduates, graduate students, and scientists researching cellular responses to DNA damage. This second edition presents new material on developments in the field over the past decade, while maintaining the previous edition's historical framework. Chapters are divided into sections on sources and consequences of DNA damage, correcting altered bases in DNA, DNA repair, DNA damage tolerance and mutagenesis, and regulatory response to DNA damage in eukaryotes. The book contains a section of color clinical photos. Annotation © 2006 Book News, Inc., Portland, OR
Arshad Rahman
This interesting new book on DNA repair and mutagenesis incorporates contributions of a variety of experts. The book is designed to serve as a comprehensive and current text on how living cells respond to genomic injury and alterations resulting from both spontaneous and environmentally induced DNA damage. The purpose of this nicely produced book is to provide an excellent basis for university courses in biology as well as a solid reference source for molecular biologists working in cancer biology, recombination, transcription and gene regulation, DNA replication, environmental studies and and biological evolution. The book meets its overall objective. This book is targeted especially for researchers, clinicians, postdoctoral fellows, and graduate students in biology and related disciplines such as medicine and environmental biology. The authors are active research workers who have important contributions to their respective areas, and so have first-hand knowledge of the topics they address. This book is comprehensive, concise, well-illustrated and original. Another great feature of the book is the inclusion of more than 4,000 complete references to primary research literature. This adds to the convenience of the reader. The layout is appealing and very appropriate. This nicely produced book covers the complete spectrum of the topics dealing with the cellular responses to DNA damage and its repair. It will be of particular interest to both industrial and university based researchers working in cancer biology, environmental biology, and other related areas of molecular biology. The book deserves to be popular.
Editorials
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: DNA repair and mutagenesis from A to Z is an apt description of this book. The coverage is complete and well ordered. The prior edition was published about 10 years ago but sufficient new material has appeared that this update is justified.
Purpose: The goal is to provide a current look at all aspects of DNA repair. This is a commendable objective and is well met.
Audience: The target audience includes research fellows/investigators working in the area of DNA repair/mutagenesis, etc. The authors are recognized in the field and highly qualified.
Features: The complexity of DNA replication and the need to carefully regulate this process is clear to all investigators. Equally important is the task of maintaining the integrity of that structure in the face of stochastic changes (depurination, for example) and external insults such as radiation or toxic chemical agents. This book provides a comprehensive discussion of all aspects of DNA repair, initiating with the types of damage and causes thereof and proceeding to detailed analysis of the various methods of repair as well as host responses. A final section reviews disease states associated with defects in these various processes. Each of the chapters (30 in all) is accompanied by a comprehensive bibliography (over 10,000 primary references in all) and a short summary. Appendixes provide a list of enzyme systems and a catalogue of the diseases. Any investigator working in this area will want this book available — the coverage is extensive and at a high standard, information on closely related damage control strategies is likely to be useful, and the literature citations constitute a general resource. In addition, those wishing a better understanding of the current status of this area of science will find key aspects readily accessible.
Assessment: This book has something for almost any scientist in the life science arena. This is an important area, well served by the authors and this is the most comprehensive book available in this field. An amply justified second edition.
Arshad Rahman
This interesting new book on DNA repair and mutagenesis incorporates contributions of a variety of experts. The book is designed to serve as a comprehensive and current text on how living cells respond to genomic injury and alterations resulting from both spontaneous and environmentally induced DNA damage. The purpose of this nicely produced book is to provide an excellent basis for university courses in biology as well as a solid reference source for molecular biologists working in cancer biology, recombination, transcription and gene regulation, DNA replication, environmental studies and and biological evolution. The book meets its overall objective. This book is targeted especially for researchers, clinicians, postdoctoral fellows, and graduate students in biology and related disciplines such as medicine and environmental biology. The authors are active research workers who have important contributions to their respective areas, and so have first-hand knowledge of the topics they address. This book is comprehensive, concise, well-illustrated and original. Another great feature of the book is the inclusion of more than 4,000 complete references to primary research literature. This adds to the convenience of the reader. The layout is appealing and very appropriate. This nicely produced book covers the complete spectrum of the topics dealing with the cellular responses to DNA damage and its repair. It will be of particular interest to both industrial and university based researchers working in cancer biology, environmental biology, and other related areas of molecular biology. The book deserves to be popular.Booknews
Revising Friedberg's DNA Repair 1985, this text covers the ways in which living cells respond to genomic injury and alterations, including both spontaneous and environmentally induced DNA damage. It begins with a discussion of DNA damage and mutagenesis, and then explores all of the known DNA repair and other cellular response modes in prokaryotes and eukaryotes, including mammalian cells. A major feature of this edition is the comprehensive coverage of mutagenesis and other aspects of DNA damage tolerance in five new chapters. The final chapter is devoted to known human diseases and disease syndromes with defective cellular responses to DNA damage. Includes some 4,000 references to primary research literature. Annotation c. Book News, Inc., Portland, OR booknews.com4 Stars! from Doody