Genetic Instability in Cancer

Booknews

Contains 18 articles which discuss such topics as DNA synthesis errors and mutators; patterns of mutation in cancer cells; mismatch repair; genomic instability and tolerance to alkylating agents; the relationship of DNA methylation to cancer; neoplastic transformation: the contrasting stability of human and mouse cells; damage inducible mutagenesis: recent insights into the activities of the umu family of mutagenesis proteins; the relevance of bacterial mutators to understanding human cancer; mutation in resting cells: the role of endogenous DNA damage; TP53 tumor suppressor gene: clues to molecular carcinogenesis and cancer therapy; and the 11q23 paradigm. Color plates and illustrations. Annotation c. by Book News, Inc., Portland, Or.