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Overview
Birth is a sudden, traumatic transition of environments. Once the placental oxygen supply ceases, the foetus has only minutes to establish pulmonary oxygen transport, which requires not only inflation of the lungs, but also sudden and sustained changes in the lung circulation. Not long ago, research in this field was largely restricted to morphology and physiology. Now the powerful new tools of cellular and molecular biology have begun to shed light on the physiological processes in the developing lung and its supporting vasculature.
In 22 chapters, three main sections explore lung growth and development, vascular cell growth and differentiation, and the mechanisms of hemodynamic control in the neonate; extensive illustrations give a comprehensive picture of pulmonary circulatory development. Factors controlling vasculogenesis and angiogenesis are described by the scientists who pioneered the field. Similarly, the intracellular signaling cascades that determine proliferation or growth inhibition of fibroblasts, smooth muscle cells, and endothelial cells are also presented in an understandable manner. Finally, the role of substances, such as nitric oxide and endothelin, that control the hemodynamics of the fetal and neonatal circulations are discussed in detail, particularly in relation to the changes occurring at birth.
This book will inform basic scientists as well as the clinician and student, and should be of particular interest to pediatric cardiologists, pulmonary medicine physicians, and vascular biologists.
The book contains black-and-white illustrations.
In 22 chapters, three main sections explore lung growth and development, vascular cell growth and differentiation, and the mechanisms of hemodynamic control in the neonate; extensive illustrations give a comprehensive picture of pulmonary circulatory development. Factors controlling vascular- and angiogenesis are described by the scientists who pioneered the field. Similarly, the intracellular signaling cascades that determine proliferation or growth inhibition of fibroblasts, smooth muscle cells, and endothelial cells are also presented in an understandable manner. Finally, the role of substances, such as nitric oxide and endothelin, that control the hemodynamics of the fetal and neonatal circulations are discussed in detail, particularly in relation to the changes occurring at birth. This book will inform basic scientists as well as the clinician and student, and should be of particular interest to pediatric cardiologists, pulmonary medicine physicians, and vascular biologists.
Synopsis
Birth is a sudden, traumatic transition of environments. Once the placental oxygen supply ceases, the foetus has only minutes to establish pulmonary oxygen transport, which requires not only inflation of the lungs, but also sudden and sustained changes in the lung circulation. Not long ago, research in this field was largely restricted to morphology and physiology. Now the powerful new tools of cellular and molecular biology have begun to
shed light on the physiological processes in the developing lung and its supporting vasculature.
In 22 chapters, three main sections explore lung growth and development, vascular cell growth and differentiation, and the mechanisms of hemodynamic control in the neonate; extensive illustrations give a comprehensive picture of pulmonary circulatory development. Factors controlling vasculogenesis and angiogenesis are described by the scientists who pioneered the field. Similarly, the intracellular signaling cascades that determine proliferation or growth inhibition of fibroblasts, smooth muscle cells, and endothelial cells are also presented in an understandable manner. Finally, the role of
substances, such as nitric oxide and endothelin, that control the hemodynamics of the fetal and neonatal circulations are discussed in detail, particularly in relation to the changes occurring at birth.
This book will inform basic scientists as well as the clinician and student, and should be of particular interest to pediatric cardiologists, pulmonary medicine physicians, and vascular biologists.
Robin H. Steinhorn
This muliauthored text is a part of the American Heart Association Monograph Series. Experts in pulmonary vascular growth and remodeling during the fetal and newborn period are featured. The purpose is to summarize current research related to the developing pulmonary circulation. By doing so, the editors intend to inform the reader, as well as provide a benchmark for future progress in the field. The editors state that the book is written for the basic scientist as well as the clinician and student. Given the detail provided in the book, I believe it will be of particular interest to basic scientists and clinician-investigators in pediatric pulmonology, pediatric cardiology, neonatology, and obstetricians specializing in perinatology. The contributors are all top-notch experts in their respective fields. The book is divided into three main sections, which follow a natural progression in emphasis from early lung development and vasculogenesis, to vascular cell growth and differentiation, to pulmonary vascular changes that occur as the fetus becomes a newborn. In each section a topic is examined in exceptional detail, with focus on cell types, mechanical forces, and potential signaling mechanisms responsible for the dramatic changes in pulmonary vascular resistance that occur during fetal and newborn life. Important information about abnormal development and stimuli are included throughout. The book is well illustrated with figures demonstrating histology, scientific results, and valuable diagrams of proposed mechanisms of vascular control. The topic of pulmonary vascular development during fetal and newborn life is often "buried" in more global pulmonary texts. This monograph is awelcome reversal in emphasis. It is a unique and valuable text, providing the investigator and clinician with "one-stop shopping" for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life.
Editorials
From The Critics
Reviewer: Robin H. Steinhorn, MD(Northwestern University Feinberg School of Medicine)Description: This muliauthored text is a part of the American Heart Association Monograph Series. Experts in pulmonary vascular growth and remodeling during the fetal and newborn period are featured.
Purpose: The purpose is to summarize current research related to the developing pulmonary circulation. By doing so, the editors intend to inform the reader, as well as provide a benchmark for future progress in the field.
Audience: The editors state that the book is written for the basic scientist as well as the clinician and student. Given the detail provided in the book, I believe it will be of particular interest to basic scientists and clinician-investigators in pediatric pulmonology, pediatric cardiology, neonatology, and obstetricians specializing in perinatology. The contributors are all top-notch experts in their respective fields.
Features: The book is divided into three main sections, which follow a natural progression in emphasis from early lung development and vasculogenesis, to vascular cell growth and differentiation, to pulmonary vascular changes that occur as the fetus becomes a newborn. In each section a topic is examined in exceptional detail, with focus on cell types, mechanical forces, and potential signaling mechanisms responsible for the dramatic changes in pulmonary vascular resistance that occur during fetal and newborn life. Important information about abnormal development and stimuli are included throughout. The book is well illustrated with figures demonstrating histology, scientific results, and valuable diagrams of proposed mechanisms of vascular control.
Assessment: The topic of pulmonary vascular development during fetal and newborn life is often "buried" in more global pulmonary texts. This monograph is a welcome reversal in emphasis. It is a unique and valuable text, providing the investigator and clinician with "one-stop shopping" for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life.
From the Publisher
"Four Stars! ****
"The Contributors are all top-notch experts in their respective fields...In each section a topic is examined in exceptional detail.
"...a unique and valuable text, providing the investigator and clinician with ‘one-stop shopping’ for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life."
Doody’s Review Service
"...a most excellent work, The Fetal and Neonatal Pulmonary Circulation aims to "inform the basic scientist as well as the clinician and student, and to provide a benchmark in the field as we approach the next millennium." The resulting text serves these ambitions superbly.
"The editors have selected an impressive group of experts to contribute chapters which cover a wide range of topics, from the history of fetal and neonatal pulmonary vascular physiology, to vascular-cell growth and differentiation, to the factors and disorders, including congenital diaphragmatic hernia, which affect pulmonary hemodynamics in the newborn.
"...In an era in which the distance between the basic scientist and busy clinician seems to be ever wider, I am particularly impressed by the way in which basic science and clinical medicine fuse into a continuum in this excellent book. The Fetal and Neonatal Pulmonary Circulation shows that when we try to work together, we can. It must be the definitive work in the area. More of the same in other areas of medicine please."
The Lancet
Robin H. Steinhorn
This muliauthored text is a part of the American Heart Association Monograph Series. Experts in pulmonary vascular growth and remodeling during the fetal and newborn period are featured. The purpose is to summarize current research related to the developing pulmonary circulation. By doing so, the editors intend to inform the reader, as well as provide a benchmark for future progress in the field. The editors state that the book is written for the basic scientist as well as the clinician and student. Given the detail provided in the book, I believe it will be of particular interest to basic scientists and clinician-investigators in pediatric pulmonology, pediatric cardiology, neonatology, and obstetricians specializing in perinatology. The contributors are all top-notch experts in their respective fields. The book is divided into three main sections, which follow a natural progression in emphasis from early lung development and vasculogenesis, to vascular cell growth and differentiation, to pulmonary vascular changes that occur as the fetus becomes a newborn. In each section a topic is examined in exceptional detail, with focus on cell types, mechanical forces, and potential signaling mechanisms responsible for the dramatic changes in pulmonary vascular resistance that occur during fetal and newborn life. Important information about abnormal development and stimuli are included throughout. The book is well illustrated with figures demonstrating histology, scientific results, and valuable diagrams of proposed mechanisms of vascular control. The topic of pulmonary vascular development during fetal and newborn life is often "buried" in more global pulmonary texts. This monograph is awelcome reversal in emphasis. It is a unique and valuable text, providing the investigator and clinician with "one-stop shopping" for timely, detailed, and important information about pulmonary vascular development during fetal and newborn life.Booknews
Specialists in cardiovascular and pulmonary research as well as pediatric specialists from around the world have contributed to this volume to examine the status of the field of fetal and neonatal pulmonary circulations. The editors list four main areas of focus: 1) the cellular and molecular factors controlling vasculogenesis; 2) the genetic and molecular factors responsible for vascular cell differentiation; 3) the role of the extracellular matrix in regulating vascular cell proliferation and activity; and 4) the mechanisms controlling tone in the transition at birth. Annotation c. Book News, Inc., Portland, OR (booknews.com)4 Stars! from Doody