Biology - Microbiology, Pathology, Biology - Bacteriology, Pharmacology, Microbiology
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Overview
This text provides the student with an understanding of the basic genetic processes of bacterial infection in humans and other animals. Beginning with an analysis of bacterial survival the author goes on to relate this to the molecular biology of virulence as exhibited in a wide variety of clinically important bacteria. How bacteria get into cells, and once inside they chemically disrupt them is examined from a molecular genetic perspective. Chapters on the location and organisation of bacterial genes allow the reader an insight into virulence right down to the level of DNA topology and supercoiling. Included in this lucid and up to date analysis are discussions on the potential for effective intervention and new strategies in antimicrobial chemotherapy and novel vaccinesAddresses plasmids/genome rearrangements/transcriptional regulation/coordinated control of gene expression/etc.
Editorials
Booknews
Presents a review of the gene regulatory circuits that underlie major bacterial pathogenic processes, placing each regulatory system in the context of existing information on bacterial gene regulation. To that end, background information is provided on fundamental topics such as transcriptional and post-transcriptional regulation, general and site- specific recombination, transposition, replicon structure (primarily chromosomes and plasmids) and genome structure. The important topic of regulation of gene expression in response to the environment is covered at length. Annotation c. Book News, Inc., Portland, OR (booknews.com)Book Details
Published
May 11, 1994
Publisher
Oxford ; Blackwell Scientific Publications, 1994.
Pages
392
Format
Paperback
ISBN
9780632036622