Human Molecular Genetics

From The Critics

Reviewer: Roger W. Melvold, PhD(Northwestern University Feinberg School of Medicine)
Description: This book provides a compendium of techniques for molecular analysis in human genetics, with an emphasis on genes related to human diseases. More than 70 authors contribute 26 chapters covering a wide range of techniques.
Purpose: It is intended to provide a collection of laboratory procedures for the molecular analysis of the human genome.
Audience: The book's primary value is to investigators using molecular techniques in human genetics. It would also be useful to some extent to those may wish to understand the techniques/procedures without actually using them.
Features: The chapters are logically arranged into seven sections (mutation detection; gene mapping, cloning and sequencing; transcription; RNA editing, ribosome and antisense RNA; recombination and amplification; receptors and signal transduction; mouse models for human molecular genetics). Each chapter contains an introductory description of the technique and its primary applications. This is followed by detailed descriptions of the preparation of reagents and the experimental laboratory procedures that take the reader through the technique on a step-by-step basis. Each chapter ends with a brief list of pertinent references, including references up through 1994. Numerous black-and-white illustrations or gray tone photomicrographs, together with a small number of color illustrations, are included where useful and appropriate. The index is well organized and sufficiently detailed.
Assessment: This techniques book will be primarily useful to investigators, technicians, and students engaged in human genetics at the molecular level. It would also, however, be useful to those who wish only to gain an understanding of the approaches and techniques employed in human genetic analyses at this level, and to libraries in general.

Roger W. Melvold

This book provides a compendium of techniques for molecular analysis in human genetics, with an emphasis on genes related to human diseases. More than 70 authors contribute 26 chapters covering a wide range of techniques. It is intended to provide a collection of laboratory procedures for the molecular analysis of the human genome. The book's primary value is to investigators using molecular techniques in human genetics. It would also be useful to some extent to those may wish to understand the techniques/procedures without actually using them. The chapters are logically arranged into seven sections (mutation detection; gene mapping, cloning and sequencing; transcription; RNA editing, ribosome and antisense RNA; recombination and amplification; receptors and signal transduction; mouse models for human molecular genetics). Each chapter contains an introductory description of the technique and its primary applications. This is followed by detailed descriptions of the preparation of reagents and the experimental laboratory procedures that take the reader through the technique on a step-by-step basis. Each chapter ends with a brief list of pertinent references, including references up through 1994. Numerous black-and-white illustrations or gray tone photomicrographs, together with a small number of color illustrations, are included where useful and appropriate. The index is well organized and sufficiently detailed. This techniques book will be primarily useful to investigators, technicians, and students engaged in human genetics at the molecular level. It would also, however, be useful to those who wish only to gain an understanding of the approaches and techniques employed in humangenetic analyses at this level, and to libraries in general.

3 Stars from Doody