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Overview
A collection of new and essential molecular techniques for cardiovascular research. These readily reproducible methods range widely from producing congenic, consomic, transgenic, and knockout models of hypertension to the gene transfer of specific genetic material using nonviral (polymers, liposomes, and antisense agents) and adenoviral vectors. Additional techniques described include single nucleotide polymorphism (SNP) genotyping, RNA interference, microarray analysis, pharmacogenetics, and pharmacogenomics for the genetic dissection of hypertension, as well as a practical method for deriving cardiomyocytes from embryonic stem cells that would serve as replacement cells for those damaged by hypertension or heart attack. The book offers both novice and experienced hypertension researchers an indispensable collection of readily reproducible techniques for successful research, work that has already dramatically improved the outlook for hypertensive patients, and promises much future success.
Editorials
From The Critics
Reviewer: Michael C Cunningham, M.D.(Ochsner Clinic Foundation)Description: This multiauthored book on hypertension is divided into seven distinct sections. The first section demonstrates models of hypertension with each subsequent section focusing on particular research modalities and protocols used to investigate the pathophysiology of hypertension.
Purpose: The book is intended to educate readers about hypertension, updating their knowledge of the current methods in hypertensive research and stimulating new ideas for further investigation.
Audience: Intended for novice and expert researchers in the field, this book concentrates on the molecular side of research. The authors specialize in this area and have gathered a wealth of information and techniques from several other sources. With this knowledge, these experts have created the reference in this field.
Features: Initially, the book demonstrates how to engineer various genetically altered mice as models for hypertension. Then, in a well outlined fashion, it discusses and expounds on the techniques of pharmacogenetics and pharmacogenomics. This includes various protein analyses and gene transfer using viral vectors and then on to assorted aspects of stem cell research. There is also a section dedicated to information technology and its indispensable role in pharmacogenomics data collection and interpretation. The illustrations are particularly well placed, usually complementing or illustrating a confusing method.
Assessment: The authors have created a much needed book in the area of molecular hypertension that serves beginners and experts in the field, not only to help them continue their current work, but also to stimulate new thought processes and ideas that will provide further insight into this deadly disease and identify new targets for pharmacologic therapy.
3 Stars from Doody