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Overview
Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effected by the blood-brain barrier, and by membrane ion pumps and other transport mechanisms of neurons and glial cells. Normally adjusted for optimal neural function, ion levels can change and alter the excitability of neurons and influence synaptic transmission in healthy and diseased brains. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.
Synopsis
Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effected by the blood-brain barrier, and by membrane ion pumps and other transport mechanisms of neurons and glial cells. Normally adjusted for optimal neural function, ion levels can change and alter the excitability of neurons and influence synaptic transmission in healthy and diseased brains. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.
Doody Review Services
Reviewer:Celso Agner, MD, MSc(University of Illinois at Chicago College of Medicine)
Description:The basic science of neurological diseases now involves the understanding of ionic transport mechanisms, in particular the inflow of metabolically important components to the cell. An update on the topic is, therefore, necessary.
Purpose:The purpose of this book is to address different aspects of ions and their influence on the metabolism of neurons. Thee are worthy objectives for scientists involved in the study of neuronal functions in normal and diseased situations.
Audience:The audience is mostly composed of neuroscientists interested in the study of the ionic influence on the metabolism of the brain.
Features:In 19 chapters and four sections, this book addresses the different forms of interaction between ions and the neuron in order to reproduce specific behaviors in the laboratory. In particular, the book departs from the handling of ions by the blood-brain barrier to the interaction of the same ions with elements of the nervous system that will determine specific characteristic neurological behaviors. This is a well illustrated and referenced book that should remain as an integral component of many neuroscience libraries.
Assessment:This is a good acquisition for neuroscience and neurology libraries, in particular in academic departments, where the interest in the correlation between ions and the brain play a significant role in the development of new treatment strategies or management reasoning.
Editorials
From The Critics
Reviewer: Celso Agner, MD, MS, MSc(Michigan Neurology Partners)Description: The basic science of neurological diseases now involves the understanding of ionic transport mechanisms, in particular the inflow of metabolically important components to the cell. An update on the topic is, therefore, necessary.
Purpose: The purpose of this book is to address different aspects of ions and their influence on the metabolism of neurons. Thee are worthy objectives for scientists involved in the study of neuronal functions in normal and diseased situations.
Audience: The audience is mostly composed of neuroscientists interested in the study of the ionic influence on the metabolism of the brain.
Features: In 19 chapters and four sections, this book addresses the different forms of interaction between ions and the neuron in order to reproduce specific behaviors in the laboratory. In particular, the book departs from the handling of ions by the blood-brain barrier to the interaction of the same ions with elements of the nervous system that will determine specific characteristic neurological behaviors. This is a well illustrated and referenced book that should remain as an integral component of many neuroscience libraries.
Assessment: This is a good acquisition for neuroscience and neurology libraries, in particular in academic departments, where the interest in the correlation between ions and the brain play a significant role in the development of new treatment strategies or management reasoning.
3 Stars from Doody