Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis
George G. Harrigan, Royston GoodacreBooks.org participates in affiliate programs including Bookshop.org and the Amazon Services LLC Associates Program. We may earn a commission from qualifying purchases made through links on this page, at no additional cost to you.
Overview
It is evident that biochemical control is not strictly hierarchical and that intermediary metabolism can contribute to control of regulatory pathways. Metabolic studies are therefore increasingly important in gene function analyses, and an increased interest in metabolites as biomarkers for disease progression or response to therapeutic intervention is also evident in the pharmaceutical industry. This book offers guidelines to currently available technology and bioinformatics and database strategies now being developed. Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.Synopsis
Biochemists and other researchers in academia and gene and pharmaceutical companies from many countries describe the technology currently available for metabolic studies in gene function analysis, and for using metabolites as biomarkers for the progression of disease or its response to therapeutic intervention. They highlight the advantages of metabolic profiling over genomic and proteomic strategies for drug discovery and development. Among the topics are metabolome and proteome profiling for characterizing microbes, Raman spectroscopy for profiling whole organisms and tissues, and bioactive lipids in reproductive diseases. Annotation ©2003 Book News, Inc., Portland, OR