Physiology, Endocrinology & Metabolism, Biochemistry - Hormones, Physiology - Biochemical Agents - General & Miscellaneous, Neurology, Physiology - Nervous System, Neurophysiology
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Overview
Going beyond step-by-step descriptions of how to perform techniques, Methods in Neuroendocrinology examines the questions that are being asked in the field, what problems need to be overcome, and what the limits of interpretation are involved in each approach. The experimental approaches described in this book merge endocrine and neuroscientific research and offer insight into the many disciplines involved.Demonstrating what can be learned from applying different approaches to neuroendocrine research, Methods in Neuroendocrinology leads the reader from elementary techniques to more complex methods for examining neuroendocrine function. The research methodology outlined addresses four main questions:
(1) What are the cellular and molecular mechanisms responsible for the synthesis and secretion of hormones?
(2) How do other cells influence neuroendocrine control mechanisms?
(3) How do hormones feed back on their neuroendocrine regulatory neurons?
(4) How can we use hormones as indicators of specific changes in neuroendocrine control sites in the brain?
Much more than a "cookbook", this is a resource for every researcher who wants to pursue new areas of inquiry in the science of neuroendocrinology.
The book contains black-and-white illustrations.
Editorials
From The Critics
Reviewer: Marie J. Gibson, PhD(Mount Sinai Medical Center)Description: This is the third book in a series entitled Cellular and Molecular Neuropharmacology . Each chapter in this volume focuses on a technique used in neuroendocrine research, an area that bridges neuroscience and endocrinology. In most cases, the chapters include some discussion of shortcomings and advantages of a particular methodology, as well as future prospects.
Purpose: The goals are twofold: to encourage those not currently engaged in neuroendocrine research to realize the interesting potential of this field, and to offer new techniques for the consideration of those already in the field.
Audience: This book is intended for students, residents, fellows, and others interested in neuroendocrine research. In most cases however, it is not a beginner's manual. With some exceptions, the chapters appear to assume an essential familiarity with the actual techniques.
Features: Among the clearest descriptions of methodology are the chapters on the use of reverse transcriptase-polymerase chain reaction to assess neuropeptide receptors, on the utility of biotinylated ligands to study binding in pituitary cells, and the description of in vivo electrophysiological approaches. An excellent analysis of the advantages and drawbacks of alternative methods for intracellular recording from hypothalamic cells is provided, and there is a thorough discussion of the issues related to quantifying pulsatility in neuroendocrine systems. Also discussed are the utility of primary neuronal cultures. Wetsel, Merchenthaler, and Liposits review their work with immortalized cells.
Assessment: For the reader interested in an overview of many of the current techniques used in neuroendocrine studies, this book provides some excellent appraisals of their respective virtues and drawbacks. In contrast to some other methods books however, this compact volume seldom provides the extensive details that may be sought by someone wishing to put a new technique into practice.
Marie J. Gibson
This is the third book in a series entitled Cellular and Molecular Neuropharmacology . Each chapter in this volume focuses on a technique used in neuroendocrine research, an area that bridges neuroscience and endocrinology. In most cases, the chapters include some discussion of shortcomings and advantages of a particular methodology, as well as future prospects. The goals are twofold: to encourage those not currently engaged in neuroendocrine research to realize the interesting potential of this field, and to offer new techniques for the consideration of those already in the field. This book is intended for students, residents, fellows, and others interested in neuroendocrine research. In most cases however, it is not a beginner's manual. With some exceptions, the chapters appear to assume an essential familiarity with the actual techniques. Among the clearest descriptions of methodology are the chapters on the use of reverse transcriptase-polymerase chain reaction to assess neuropeptide receptors, on the utility of biotinylated ligands to study binding in pituitary cells, and the description of in vivo electrophysiological approaches. An excellent analysis of the advantages and drawbacks of alternative methods for intracellular recording from hypothalamic cells is provided, and there is a thorough discussion of the issues related to quantifying pulsatility in neuroendocrine systems. Also discussed are the utility of primary neuronal cultures. Wetsel, Merchenthaler, and Liposits review their work with immortalized cells. For the reader interested in an overview of many of the current techniques used in neuroendocrine studies, this book provides someexcellent appraisals of their respective virtues and drawbacks. In contrast to some other methods books however, this compact volume seldom provides the extensive details that may be sought by someone wishing to put a new technique into practice.3 Stars from Doody
Book Details
Published
June 4, 1998
Publisher
CRC Press
Pages
256
Format
Paperback
ISBN
9780849333637