Microbial Genomics and Drug Discovery

Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly illustrates the use of pathway tools in a genomics-based drug discovery project.

Aimed at researchers in the pharmaceutical industry, this text presents a broad range of bioinformatic and genomic approaches to the problem of identifying novel antibiotic classes. Fourteen contributions from Dougherty (Pfizer, Inc.), Projan (Wyeth Research) and other researchers focus on various problems encountered when identifying, selecting, and prosecuting novel antibacterial targets. Topics include, for example, the global aspects of antibiotic resistance, the use of phenotype microarrays in antibiotic discovery, and the application of genomics to the discovery of new drugs against tuberculosis. Annotation ©2003 Book News, Inc., Portland, OR