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Overview
The drive to replace damaged tissues with 'tissue engineered' constructs has led to fundamental questions regarding the importance of cell-cell and cell-substrate interactions in achieving the desired result. Photolithographic techniques coupled with standard silane chemistry can be readily adapted to reproducibly create arrays of cells on glass substrates, allowing control over the cell-cell and cell-substrate interactions of interest. These techniques have applications in bioartificial organs, in particular, and this study focuses on the utility of microfabrication in optimization of a bioartificial liver device.Synopsis
The drive to replace damaged tissues with `tissue engineered' constructs has led to fundamental questions regarding the importance of cell-cell and cell-substrate interactions in achieving the desired result. Photolithographic techniques coupled with standard silane chemistry can be readily adapted to reproducibly create arrays of cells on glass substrates, allowing control over the cell-cell and cell-substrate interactions of interest. These techniques have applications in bioartificial organs, in particular, and this study focuses on the utility of microfabrication in optimization of a bioartificial liver device.
Booknews
In his Ph.D. dissertation for an unnamed institution, Bhatia investigates at a fundamental level the role of heterotypic cell-cell interactions in the development of functional liver tissue. He describes how he developed an adaptable method for generating two- dimensional, anisotropic model surfaces capable of organizing two different cell types in discrete spatial locations, using the primary rat hepatocyte/3T3 fibroblast cell system for experimentation because of its potential clinical significance in bioartificial liver design. He also examines the mechanisms by which hepatocytes and fibroblasts interact to produce a differentiated hepatocyte phenotype. His research has potential applications in tissue engineering, implantation biology, and developmental biology both for basic science and to develop cellular therapeutics. Annotation c. Book News, Inc., Portland, OR (booknews.com)