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Overview
This book reviews the latest findings on new vaccines research, development, and potency trials. It includes in-depth discussions of attenuated vectors, polynucleotides, AIDS, and many other subjects. Useful at both research and application levels, this work will provide all public health professionals with a tool to help in the global control of infectious diseases.The book contains black-and-white illustrations.
Synopsis
This book reviews the latest findings on new vaccines research, development, and potency trials. It includes in-depth discussions of attenuated vectors, polynucleotides, AIDS, and many other subjects. Useful at both research and application levels, this work will provide all public health professionals with a tool to help in the global control of infectious diseases.
Mark R. Schleiss
A distinguished group of authors has written a series of state-of-the-art reviews about the current science of vaccine development in this book. Though this book is succinct at under 400 pages, the topics are comprehensively considered, and novel vaccine delivery systems, such as plasmid DNA-mediated immunization, the new generation of attenuated poxviruses delivery systems, and new developments in adjuvant technology are reviewed by leading experts in the basic science of vaccine research. It is not completely clear, however, the audience to which the book is best targeted. Although the preface indicates that this book is ""addressed mainly to all public health professionals concerned with immunization programs . . .,"" in fact there is little in this book that is directly pertinent to current clinical practice. Indeed, only the chapters dealing with hepatitis B vaccine and acellular pertussis vaccine describe vaccines that are currently widely available in the clinical arena. Although there is clearly an urgent need for better vaccines for measles, tuberculosis, and parasitic diseases, especially malaria, the book suffers from a lack of an integrative focus explaining how we can anticipate that these exciting developments in vaccine research can be implemented in the clinic. For example, the author's introduction emphasizes the WHO Children's Vaccine Initiative and refers to the ""special attention"" to be given to a ""pediatric vaccine immunizing immunizing against five diseases""; however, nowhere else in the volume is there any detailed description of this pentavalent vaccine. The chapter devoted to HIV vaccines is scholarly, current, and encyclopedic in detail, with nearly 400references. However, we are still not close to having an HIV vaccine. Where do we go from here? Again, from the vantage point of the public health professional, these questions need to be considered in order to put this considerable body of basic research into an overall public health perspective. Although this is where this book falls short of expectations, it should nevertheless provide a detailed review indispensable to all physicians and scientists involved in the basic science of vaccine development, and it is this group that is most likely to find the book useful.
Editorials
From The Critics
Reviewer: Mark R. Schleiss, MD(Children's Hospital Medical Center)Description: A distinguished group of authors has written a series of state-of-the-art reviews about the current science of vaccine development in this book.
Purpose: Though this book is succinct at under 400 pages, the topics are comprehensively considered, and novel vaccine delivery systems, such as plasmid DNA-mediated immunization, the new generation of attenuated poxviruses delivery systems, and new developments in adjuvant technology are reviewed by leading experts in the basic science of vaccine research.
Audience: It is not completely clear, however, the audience to which the book is best targeted. Although the preface indicates that this book is "addressed mainly to all public health professionals concerned with immunization programs . . .," in fact there is little in this book that is directly pertinent to current clinical practice. Indeed, only the chapters dealing with hepatitis B vaccine and acellular pertussis vaccine describe vaccines that are currently widely available in the clinical arena.
Features: Although there is clearly an urgent need for better vaccines for measles, tuberculosis, and parasitic diseases, especially malaria, the book suffers from a lack of an integrative focus explaining how we can anticipate that these exciting developments in vaccine research can be implemented in the clinic. For example, the author's introduction emphasizes the WHO Children's Vaccine Initiative and refers to the "special attention" to be given to a "pediatric vaccine immunizing immunizing against five diseases"; however, nowhere else in the volume is there any detailed description of this pentavalent vaccine. The chapter devoted to HIV vaccines is scholarly, current, and encyclopedic in detail, with nearly 400 references. However, we are still not close to having an HIV vaccine.
Assessment: Where do we go from here? Again, from the vantage point of the public health professional, these questions need to be considered in order to put this considerable body of basic research into an overall public health perspective. Although this is where this book falls short of expectations, it should nevertheless provide a detailed review indispensable to all physicians and scientists involved in the basic science of vaccine development, and it is this group that is most likely to find the book useful.
Mark R. Schleiss
A distinguished group of authors has written a series of state-of-the-art reviews about the current science of vaccine development in this book. Though this book is succinct at under 400 pages, the topics are comprehensively considered, and novel vaccine delivery systems, such as plasmid DNA-mediated immunization, the new generation of attenuated poxviruses delivery systems, and new developments in adjuvant technology are reviewed by leading experts in the basic science of vaccine research. It is not completely clear, however, the audience to which the book is best targeted. Although the preface indicates that this book is ""addressed mainly to all public health professionals concerned with immunization programs . . .,"" in fact there is little in this book that is directly pertinent to current clinical practice. Indeed, only the chapters dealing with hepatitis B vaccine and acellular pertussis vaccine describe vaccines that are currently widely available in the clinical arena. Although there is clearly an urgent need for better vaccines for measles, tuberculosis, and parasitic diseases, especially malaria, the book suffers from a lack of an integrative focus explaining how we can anticipate that these exciting developments in vaccine research can be implemented in the clinic. For example, the author's introduction emphasizes the WHO Children's Vaccine Initiative and refers to the ""special attention"" to be given to a ""pediatric vaccine immunizing immunizing against five diseases""; however, nowhere else in the volume is there any detailed description of this pentavalent vaccine. The chapter devoted to HIV vaccines is scholarly, current, and encyclopedic in detail, with nearly 400references. However, we are still not close to having an HIV vaccine. Where do we go from here? Again, from the vantage point of the public health professional, these questions need to be considered in order to put this considerable body of basic research into an overall public health perspective. Although this is where this book falls short of expectations, it should nevertheless provide a detailed review indispensable to all physicians and scientists involved in the basic science of vaccine development, and it is this group that is most likely to find the book useful.Booknews
Reports the latest findings on new vaccine research, development, and potency trials. Emphasizes multivalent oral vaccines based on live attenuated vectors, which are a priority for the World Health Organization's vaccine development programs. Primarily addressed to public health professionals concerned with immunization and the control of infectious disease, but also of possible interest to vaccine producers and researchers in immunization strategies. Annotation c. Book News, Inc., Portland, OR (booknews.com)3 Stars from Doody