Molecular Diversity and Combinatorial Chemistry: Libraries and Drug Discovery

Reports progress on chemical, enzymatic, phage, and cell-derived libraries. Discusses synergy between structure-based design and combinatorial libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening approaches, including the use of NMR. Presents recent advances in solid-phase organic synthesis, liquid-phase organic synthesis, and high-throughput combinatorial organic synthesis. Discusses automation of organic synthesis as well as new methodologies for monitoring solid-phase organic synthesis.

Booknews

Presents papers from two winter 1996 conferences held in Coronado, California, in sections on solid-, solution-, and liquid-phase combinatorial synthesis in library design, biology-based chemical libraries, automated solid-phase synthesis, analytical methods and screening, and applications. Subjects include integration of high- throughput chemistry and structure-based drug design, mixtures of molecules versus mixtures of pure compounds on polymeric beads, living libraries using gene transfer, software for automated design of combinatorial libraries, and use of combinatorial libraries in the development of novel anti-infectives. Annotation c. by Book News, Inc., Portland, Or.