Overview
MAPs have undergone a fascinating history, beginning with injury potentials in 1883, and undergoing a remarkable renaissance over the last 30 years in many areas of electrophysiology research, both basic and clinical. Since 1986, the contact electrode technique has provided a unique means to test basic research concepts in the intact or in vivo human heart. Even so, observations in clincal elctrophysiology still warrant further exploration in basic science.Scientific experts in the field have contributed to this volume their latest data on myocardial repolarization and the many factors that modulate normal and abnormal repolorization, to the benefit of electrophysiologists, cardiologists, clinicians as well as pharmaceutical researchers involved in the development of aniarrhythmic drugs. By concentrating on the electrical activity of the in situ heart, this timely and informative reference brings to light information that cannot be obtained by any other means.
The book contains predominantly black-and-white illustrations, with some color illustrations.
MAPs using the contact electrode technique provide a unique means to test basic research concepts in the intact, or in vivo, human heart. This work's detailed overview of MAP techniques highlights: 1) how to use the technique properly in patients to obtain high-quality signals and avoid artifacts; 2) how to use computers for automated analyses of the MAP signals; 3) a thorough evaluation of the basic theory underlying the genesis of the monophasic action potential signal; 4) the possibility to compare directly in an intact heart (animal or human) the direct myocardial action potential with the body surface ECG; and 5) the limitations and possible new frontiers of this technique. Along with new techniques, such as single-catheter pacing and MAP recording, chapters feature new understandings about heart rate, antiarrhythmic drugs, mechanoelectrical feedback, dispersion of ventricular repolarization, detection of arrhythmia triggers, ventricular fibrillation, and antiarrhythmic device-related uses of MAP recordings. Experts from around the world have contributed their latest data to this volume:to the benefit of electrophysiologists and cardiologists, as well as pharmaceutical researchers involved in the development of antiarrhythmic drugs. This timely and informative text brings to light information that cannot be obtained by any other means.
Editorials
From The Critics
Reviewer: Robert J. Hariman, MD, FACC(Loyola University Stritch School of Medicine)Description: This is a multiauthored book on the use of monophasic action potential (MAP) recording of the intact heart. As the title indicates, this technique provides a bridge between cellular recording and repolarization characteristics related to different clinical scenarios.
Purpose: The purpose is to describe the use of MAP recording to provide better insights into the repolarization-related electrophysiological phenomena. The world experts writing this book achieved this goal in describing results in different clinical situations.
Audience: This book is best intended for basic scientists and clinical electrophysiologists interested in understanding phenomena related to repolarization of the heart.
Features: Various topics related to the recording technique, rate dependent repolarization changes in normal and ischemic myocardium, dispersion of repolarization, and evaluation of different mechanisms of arrhythmias are covered. The illustrations are educational and the references are current.
Assessment: This is an excellent book on MAP recording in the intact heart. The comprehensive information contained in this book is applicable to basic understanding of various arrhythmias.
Robert J. Hariman
This is a multiauthored book on the use of monophasic action potential (MAP) recording of the intact heart. As the title indicates, this technique provides a bridge between cellular recording and repolarization characteristics related to different clinical scenarios. The purpose is to describe the use of MAP recording to provide better insights into the repolarization-related electrophysiological phenomena. The world experts writing this book achieved this goal in describing results in different clinical situations. This book is best intended for basic scientists and clinical electrophysiologists interested in understanding phenomena related to repolarization of the heart. Various topics related to the recording technique, rate dependent repolarization changes in normal and ischemic myocardium, dispersion of repolarization, and evaluation of different mechanisms of arrhythmias are covered. The illustrations are educational and the references are current. This is an excellent book on MAP recording in the intact heart. The comprehensive information contained in this book is applicable to basic understanding of various arrhythmias.Booknews
Two forewords, one by a basic scientist and the other by a clinical electrophysiologist, signal at once the bicameral nature of the hefty reference. Practical and theoretical treatments of the same topic are juxtaposed for quick cross-referencing. The focus is how the potentials can be used to increase the understanding of repolarization-related electrophysiology and abnormalities leading to arrhythmias by experimenting on intact human hearts. The 50 papers cover methodology, rate-dependent modulation of the action potential duration in normal and ischemic myocardia, the dispersion of ventricular repolarization and refractoriness, evaluating anti- arrhythmic drug effects, torsades de pointes and other triggered ventricular arrhythmias, mechano-electrical feedback, ventricular fibrillation and defibrillation, and anti-arrhythmic device-related uses of monophasic action potential recording. Annotation c. Book News, Inc., Portland, OR (booknews.com)3 Stars from Doody