Negative Staining

Booknews

Examines theory and practice, and reports on recent advances. Hayat and Miller provide practical guidelines on the procedures involved when performing most of the routinely used methods for negative staining and also analyze the detection and identification of viruses--the major application of this technique (the most useful of all the microscopist's tricks). Typical discussions deal with identifying human viruses in urine, feces, blood serum, the gastrointestinal tract, and cerebrospinal fluid; detecting viruses in animal, plant, insect, and bacterial specimens; comparing viral nucleic acids; localizing antigens within virus particles; and studying ribosomal subunits and protein macromolecules. Annotation c. Book News, Inc., Portland, OR (booknews.com)