Otolaryngology, Human Anatomy - Gross Anatomy, Toxicology, Biochemistry - General & Miscellaneous, Anatomy, Pharmacology

Ototoxicity

Name: Ototoxicity
Author: Peter S. Roland, John A. Rutka
ISBN: 9781550092639

by Peter S. Roland, John A. Rutka

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Overview

Roland (otolaryngology, head and neck surgery, U. of Texas Southwestern Medical Center at Dallas, US), Rutka (otolaryngology, U. of Toronto, Canada) and their colleagues review the major medical aspects of the functional impairment and cellular damage to the tissues of the inner ear caused by certain substances, a number of which are used in various medical applications. The 23 chapters begin with anatomy and physiology and then review the toxicity of such substances as loop diuretic, cisplatin, platinum compounds, iron chelating and other chemotherapeutic agents, aminoglycoside, and macrolides. The topical toxic effects of ototopical agents, aminoglycoside, antifungals, surgical disinfectants and antiseptics, and other substances are then examined. Later chapters discuss genetic factors in aminoglycoside ototoxicity, audiologic monitoring, ototoxic damage to hearing and therapies, treatment of Meniere's disease, and medicolegal aspects. The included CD-ROM contains the text and illustrations from the book in searchable electronic form (PDF). Annotation © 2006 Book News, Inc., Portland, OR

Synopsis

Ototoxicity is a compendium of information on the ototoxic potential of clinically useful drugs. Each section of this thorough text is written by a leading authority in the field. The book reviews the important classes of medications known to cause ototoxicity and their mechanisms. Clinical manifestations, what is known about pathophysiology, strategies for prevention and treatment, and medical-legal issues for each class of compounds are reviewed. Auditory and vestibular monitoring and new therapeutic strategies that may prevent or minimize ototoxicity are highlighted in addition to discussing recent advances in protective therapy. Also included is the therapeutic use of the ototoxic properties of aminoglycosides in the clinical treatment of inner ear dysfunction.