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Overview
In the last two decades, our knowledge on regulatory peptides and their cognate receptors, most of which are members of the seven transmembrane receptor families, has increased enormously. Regulatory peptides are small proteins which, besides their hormonal functions in regulating cellular metabolism in various tissues, may also act as neurotransmitters, and thus they often carry the prefix "neuro". Many of the cognate receptors involved in transducing the peptidergic signal across the cell membrane via a family of G proteins exist in multiple forms, the number of which frequently exceeds that of the corresponding peptide ligands. In this book, various peptide-receptor systems are discussed, e.g. CRF, somatostatin, TRH, opioid peptides, vasopressin, and oxyin. It also discusses new strategies such as "reverse physiology" to uncover new peptides and orphan receptors.
The book contains black-and-white illustrations.
Editorials
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: This is Volume 26 in a series entitled Results and Problems in Cell Differentiation.
Purpose: Recent work in the field of bioactive peptides has led to a major increase in both identification and understanding, and this provides the impetus for this book.
Audience: The audience is anyone working with either peptides or their receptors.
Features: A short introductory chapter on the evolutionary puzzle of initial origin (peptide or receptor) is followed by brief reviews of most of the pituitary peptides, and several of their receptors. Neurotransmitter peptides, galanin, cholecystokinin, and orphan receptors are covered in subsequent chapters. Authorship of each section is by experienced investigators and the overall quality of coverage is high. Each chapter is accompanied by a useful bibliography.
Assessment: The focus of this book is limited to peptides of mammalian origin, which limits discussions of evolution and function in lower animals. Nevertheless, this volume will be of interest to scientists active in the field.
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: This is Volume 26 in a series entitled Results and Problems in Cell Differentiation.
Purpose: Recent work in the field of bioactive peptides has led to a major increase in both identification and understanding, and this provides the impetus for this book.
Audience: The audience is anyone working with either peptides or their receptors.
Features: A short introductory chapter on the evolutionary puzzle of initial origin (peptide or receptor) is followed by brief reviews of most of the pituitary peptides, and several of their receptors. Neurotransmitter peptides, galanin, cholecystokinin, and orphan receptors are covered in subsequent chapters. Authorship of each section is by experienced investigators and the overall quality of coverage is high. Each chapter is accompanied by a useful bibliography.
Assessment: The focus of this book is limited to peptides of mammalian origin, which limits discussions of evolution and function in lower animals. Nevertheless, this volume will be of interest to scientists active in the field.
Eugene A. Davidson
This is Volume 26 in a series entitled Results and Problems in Cell Differentiation. Recent work in the field of bioactive peptides has led to a major increase in both identification and understanding, and this provides the impetus for this book. The audience is anyone working with either peptides or their receptors. A short introductory chapter on the evolutionary puzzle of initial origin (peptide or receptor) is followed by brief reviews of most of the pituitary peptides, and several of their receptors. Neurotransmitter peptides, galanin, cholecystokinin, and orphan receptors are covered in subsequent chapters. Authorship of each section is by experienced investigators and the overall quality of coverage is high. Each chapter is accompanied by a useful bibliography. The focus of this book is limited to peptides of mammalian origin, which limits discussions of evolution and function in lower animals. Nevertheless, this volume will be of interest to scientists active in the field.3 Stars from Doody