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Overview
The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the field's most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought the daring new idea to its current position of imminent practical success. This is a book designed to endure as clinical advances accumulate, a clear-eyed work of reference that will anchor the further development of this revolution in therapy. It is an essential addition to libraries of clinical medicine, biotechnology, and public policy, and a resource that no laboratory investigator with an interest in the biology of gene transfer should be without."...chronicles the evolution of human gene therapy, illustrating how imaginative concepts have shaped the development of technologies & brought the new idea to its current position of imminent practical success."
Editorials
Nature Magazine
Highlights of this large volume include an excellent chapter on naked DNA injection into various tissues. The fact that this leads to gene expression at all is remarkably encouraging for the future. Another chapter considers targeted gene repair in mammalian cells using chimaeric oligonucleotides. Although a long way from the clinic, this represents the beginnings of genetic surgery. The short review on stem-cell transplantation is concise, yet informative, while the ethics of the subject are well reviewed in a historical context.Science Magazine
The Development of Human Gene Therapy is a timely and useful book that highlights the significant recent advances in the field. At the same time, it illuminates the important hurdles that remain to be overcome en route to a clinically useful reality.Booknews
Contributors from inside the discipline trace the unconventional 30- year development of gene therapy, which was widely accepted by the medical community and society at large long before there were any practical clinical results. They describe specific topics such as retroviral and lentiviral vectors, advances in synthetic gene-delivery system technology, naked DNA gene transfer in mammalian cells, the hematopoietic system as a target for gene therapy, suicide genes, the logic of anti-angiogenic gene therapy, apoptosis as a goal of cancer gene therapy, therapy for HIV and other viral infections, public policy and regulatory issues, and ethical issues in human gene transfer research. Annotation c. by Book News, Inc., Portland, Or.Book Details
Published
December 11, 1998
Publisher
Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, c1999.
Pages
744
Format
Hardcover
ISBN
9780879695286