Overview
Designed to distill the principles and facts of pharmacokinetics effectively, the Handbook of Basic Pharmacokinetics ... Including Clinical Applications is a great resource on the most relevant scientific information for students, researchers, and practitioners. Readers will find the book current, accurate, comprehensive, and clinically useful. A chapter titled "Pharmacogenetics and Pharmacogenomics" addresses the influence of genetic constitution on the enzymes and transporters that affect drug disposition and action.
Synopsis
First published in 1976, the Handbook of Basic Pharmacokinetics . . . Including Clinical Applications is known for being a user-friendly consolidation of pharmacokinetic principles and techniques for practitioners, researchers, and students that merits a place in any personal or college library. In this seventh edition, 10 chapters have been substantially revised to address recent developments and incorporate new information, illustrations, and equations and up-to-date literature citations. The appendix has been expanded to include parameters for some 150 additional drugs, bringing the total to more than 790. Key Features:
Chapters on the following topics have been updated: Absorption/Transport Mechanisms, Physicochemical and Biological Factors Affecting in vivo Performance of Drugs, Drug Biotransformation, Excretion and Clearance of Drugs, Pediatric Pharmacokinetics, First-Dose Size in Man, Correlation of Clinical Response with Drug Disposition, Bioavailability and Bioequivalence, Extracorporeal Methods of Drug Removal, and Pharmacogenetics and Pharmacogenomics.
More than 100 pharmacokinetic terms are defined in Chapter 1.
Pharmacokinetic data compiled from the literature on nearly 800 drugs-150 new to this edition-are presented in the tabular appendix.
Doody Review Services
Reviewer:Melissa M. Ranieri, BS, PharmD(Temple University School of Pharmacy)
Description:This accessible reference of key pharmacokinetic concepts and equations also includes a comprehensive appendix of pharmacokinetic parameters for nearly 800 drugs. This edition (the last edition was published in 2004) includes revised chapters with updated information and illustrations.
Purpose:It is intended as an easy to use reference on basic pharmacokinetic concepts for students or healthcare professionals who use these principles in their practice. The book is effective in explaining important principles and is easy to understand.
Audience:The audience includes healthcare practitioners who wish to review basic pharmacokinetic parameters, researchers who would like to apply these parameters to drug design, or students learning these concepts for the first time. Pharmacokinetic principles, which are sometimes perceived as complicated and elusive, are clearly explained in a thorough manner. The authors are extensively trained in pharmacokinetics and are professors of pharmacology and pharmacokinetics and have collaborated with experts in the field to update information in this edition.
Features:The handbook reviews concepts such as the LADMER system (drug liberation, absorption, distribution, metabolism, and elimination) and key principles such as area under the curve, drug compartment models, and drug elimination curves. The book is particularly effective in explaining how pharmacokinetic parameters are individualized based on the patient (e.g., pediatric, geriatric, obese, or pregnant). The appendix, which includes a comprehensive list of medications and their individual pharmacokinetic parameters, such as half-life, volume of distribution, and dosage, is a nice feature. Illustrations and tables are effective at helping readers understand challenging concepts, although the illustrations could be improved by enlarging some of the more elaborate drawings. The text flows nicely and is organized and easy to understand.
Assessment:This is a comprehensive, easy to understand reference on basic pharmacokinetic principles. This edition includes updated information with current references. The appendix of pharmacokinetic parameters, definitions, illustrations, and list of equations are effective at reinforcing material. Overall, the book is successful in explaining complicated pharmacokinetic concepts in a manner that is easy to understand and can be quickly referenced.
Editorials
From The Critics
Reviewer: Melissa M. Ranieri, BS, PharmD(Temple University School of Pharmacy)Description: This accessible reference of key pharmacokinetic concepts and equations also includes a comprehensive appendix of pharmacokinetic parameters for nearly 800 drugs. This edition (the last edition was published in 2004) includes revised chapters with updated information and illustrations.
Purpose: It is intended as an easy to use reference on basic pharmacokinetic concepts for students or healthcare professionals who use these principles in their practice. The book is effective in explaining important principles and is easy to understand.
Audience: The audience includes healthcare practitioners who wish to review basic pharmacokinetic parameters, researchers who would like to apply these parameters to drug design, or students learning these concepts for the first time. Pharmacokinetic principles, which are sometimes perceived as complicated and elusive, are clearly explained in a thorough manner. The authors are extensively trained in pharmacokinetics and are professors of pharmacology and pharmacokinetics and have collaborated with experts in the field to update information in this edition.
Features: The handbook reviews concepts such as the LADMER system (drug liberation, absorption, distribution, metabolism, and elimination) and key principles such as area under the curve, drug compartment models, and drug elimination curves. The book is particularly effective in explaining how pharmacokinetic parameters are individualized based on the patient (e.g., pediatric, geriatric, obese, or pregnant). The appendix, which includes a comprehensive list of medications and their individual pharmacokinetic parameters, such as half-life, volume of distribution, and dosage, is a nice feature. Illustrations and tables are effective at helping readers understand challenging concepts, although the illustrations could be improved by enlarging some of the more elaborate drawings. The text flows nicely and is organized and easy to understand.
Assessment: This is a comprehensive, easy to understand reference on basic pharmacokinetic principles. This edition includes updated information with current references. The appendix of pharmacokinetic parameters, definitions, illustrations, and list of equations are effective at reinforcing material. Overall, the book is successful in explaining complicated pharmacokinetic concepts in a manner that is easy to understand and can be quickly referenced.
From The Critics
Reviewer:Melissa M. Ranieri, BS, PharmD(Temple University School of Pharmacy)Description:This accessible reference of key pharmacokinetic concepts and equations also includes a comprehensive appendix of pharmacokinetic parameters for nearly 800 drugs. This edition (the last edition was published in 2004) includes revised chapters with updated information and illustrations.
Purpose:It is intended as an easy to use reference on basic pharmacokinetic concepts for students or healthcare professionals who use these principles in their practice. The book is effective in explaining important principles and is easy to understand.
Audience:The audience includes healthcare practitioners who wish to review basic pharmacokinetic parameters, researchers who would like to apply these parameters to drug design, or students learning these concepts for the first time. Pharmacokinetic principles, which are sometimes perceived as complicated and elusive, are clearly explained in a thorough manner. The authors are extensively trained in pharmacokinetics and are professors of pharmacology and pharmacokinetics and have collaborated with experts in the field to update information in this edition.
Features:The handbook reviews concepts such as the LADMER system (drug liberation, absorption, distribution, metabolism, and elimination) and key principles such as area under the curve, drug compartment models, and drug elimination curves. The book is particularly effective in explaining how pharmacokinetic parameters are individualized based on the patient (e.g., pediatric, geriatric, obese, or pregnant). The appendix, which includes a comprehensive list of medications and their individual pharmacokinetic parameters, such as half-life, volume of distribution, and dosage, is a nice feature. Illustrations and tables are effective at helping readers understand challenging concepts, although the illustrations could be improved by enlarging some of the more elaborate drawings. The text flows nicely and is organized and easy to understand.
Assessment:This is a comprehensive, easy to understand reference on basic pharmacokinetic principles. This edition includes updated information with current references. The appendix of pharmacokinetic parameters, definitions, illustrations, and list of equations are effective at reinforcing material. Overall, the book is successful in explaining complicated pharmacokinetic concepts in a manner that is easy to understand and can be quickly referenced.
From The Critics
Reviewer: Melissa M. Ranieri, BS, PharmD(Temple University School of Pharmacy)Description: This accessible reference of key pharmacokinetic concepts and equations also includes a comprehensive appendix of pharmacokinetic parameters for nearly 800 drugs. This edition (the last edition was published in 2004) includes revised chapters with updated information and illustrations.
Purpose: It is intended as an easy to use reference on basic pharmacokinetic concepts for students or healthcare professionals who use these principles in their practice. The book is effective in explaining important principles and is easy to understand.
Audience: The audience includes healthcare practitioners who wish to review basic pharmacokinetic parameters, researchers who would like to apply these parameters to drug design, or students learning these concepts for the first time. Pharmacokinetic principles, which are sometimes perceived as complicated and elusive, are clearly explained in a thorough manner. The authors are extensively trained in pharmacokinetics and are professors of pharmacology and pharmacokinetics and have collaborated with experts in the field to update information in this edition.
Features: The handbook reviews concepts such as the LADMER system (drug liberation, absorption, distribution, metabolism, and elimination) and key principles such as area under the curve, drug compartment models, and drug elimination curves. The book is particularly effective in explaining how pharmacokinetic parameters are individualized based on the patient (e.g., pediatric, geriatric, obese, or pregnant). The appendix, which includes a comprehensive list of medications and their individual pharmacokinetic parameters, such as half-life, volume of distribution, and dosage, is a nice feature. Illustrations and tables are effective at helping readers understand challenging concepts, although the illustrations could be improved by enlarging some of the more elaborate drawings. The text flows nicely and is organized and easy to understand.
Assessment: This is a comprehensive, easy to understand reference on basic pharmacokinetic principles. This edition includes updated information with current references. The appendix of pharmacokinetic parameters, definitions, illustrations, and list of equations are effective at reinforcing material. Overall, the book is successful in explaining complicated pharmacokinetic concepts in a manner that is easy to understand and can be quickly referenced.