Books.org participates in affiliate programs including Bookshop.org and the Amazon Services LLC Associates Program. We may earn a commission from qualifying purchases made through links on this page, at no additional cost to you.
Overview
"Glycobiology is now taking a central role in our understanding of cell function. This book is a comprehensive update of recent progress in the area, with emphasis on the structure, biosynthesis and function of carbohydrates in development and disease. Topics covered include: cell-type specific expression of cell surface carbohydrates, the roles of cell surface carbohydrates in leukocyte-endothelium interaction, O-GlcNAc glycoproteins in the nucleus and cytoplasm, the roles of sphingolipids and glycosphingolipids in membranes, and transgenic approaches to the analysis of carbohydrate function." "Molecular and Cellular Glycobiology also describes in detail our current knowledge of diseases caused by anomalies of carbohydrate biosynthesis and approaches to develop therapeutic agents based on carbohydrates." "Molecular and Cellular Glycobiology covers recent developments in this important field in a comprehensive yet focused manner. It will be of major interest to all researchers who study carbohydrates or biological molecules modified by glycosylation."--BOOK JACKET.The book contains predominantly black-and-white illustrations, with some color illustrations.
Synopsis
This book covers the recent progress in understanding the biological roles of carbohydrates and includes basic knowledge of carbohydrates in mammals. Emphasis is on structure, biosynthesis and function of carbohydrates in development and disease, in particular, biological significance in immune cells, neural cells and cytoplasmic and nuclear proteins. It also updates the knowledge of diseases caused by anomalies of carbohydrate biosynthesis and the animal models used to investigate the physiological roles of carbohydrates including carbohydrates attached to lipids and attempts to develop therapeutic agents based on carbohydrates.
Eugene A. Davidson
The field of glycobiology has lagged somewhat behind that of protein and nucleic acid biology primarily because of the technical difficulties associated with saccharide chemistry. This volume highlights several recent developments in the area and can serve as an introduction to current work. The focus is on the role of glycoconjugates in recognition, regulation, and development. Investigators interested in the areas discussed will find authoritative reviews with helpful bibliographies. The first chapter reviews the structures of N- and O-linked glycans. This is followed by sections on the function of cell surface carbohydrates in recognition and development. A discussion of deficiency diseases reviews recent work on specific enzymatic defects that lead to incompletely glycosylated proteins. A chapter on transgenic animals reviews what is currently known about knockouts. There is a short discussion of the role of some glycolipids, cytosolic O-glycosylation, and a recap of potential saccharide based drugs. The volume makes no attempt to be comprehensive and does not discuss recent work on proteoglycans or studies on the conformational effects of saccharide substitution on proteins. Those interested in the role of these molecules in plants will turn elsewhere.
Editorials
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: The field of glycobiology has lagged somewhat behind that of protein and nucleic acid biology primarily because of the technical difficulties associated with saccharide chemistry.
Purpose: This volume highlights several recent developments in the area and can serve as an introduction to current work. The focus is on the role of glycoconjugates in recognition, regulation, and development.
Audience: Investigators interested in the areas discussed will find authoritative reviews with helpful bibliographies.
Features: The first chapter reviews the structures of N- and O-linked glycans. This is followed by sections on the function of cell surface carbohydrates in recognition and development. A discussion of deficiency diseases reviews recent work on specific enzymatic defects that lead to incompletely glycosylated proteins. A chapter on transgenic animals reviews what is currently known about knockouts. There is a short discussion of the role of some glycolipids, cytosolic O-glycosylation, and a recap of potential saccharide based drugs.
Assessment: The volume makes no attempt to be comprehensive and does not discuss recent work on proteoglycans or studies on the conformational effects of saccharide substitution on proteins. Those interested in the role of these molecules in plants will turn elsewhere.
Eugene A. Davidson
The field of glycobiology has lagged somewhat behind that of protein and nucleic acid biology primarily because of the technical difficulties associated with saccharide chemistry. This volume highlights several recent developments in the area and can serve as an introduction to current work. The focus is on the role of glycoconjugates in recognition, regulation, and development. Investigators interested in the areas discussed will find authoritative reviews with helpful bibliographies. The first chapter reviews the structures of N- and O-linked glycans. This is followed by sections on the function of cell surface carbohydrates in recognition and development. A discussion of deficiency diseases reviews recent work on specific enzymatic defects that lead to incompletely glycosylated proteins. A chapter on transgenic animals reviews what is currently known about knockouts. There is a short discussion of the role of some glycolipids, cytosolic O-glycosylation, and a recap of potential saccharide based drugs. The volume makes no attempt to be comprehensive and does not discuss recent work on proteoglycans or studies on the conformational effects of saccharide substitution on proteins. Those interested in the role of these molecules in plants will turn elsewhere.Booknews
Provides an update of recent progress in the area of glycobiology, emphasizing the structure, biosynthesis, and function of carbohydrates in development and disease. Topics covered include cell-type specific expression of cell surface carbohydrates, the roles of cell surface carbohydrates in leukocyte-endothelium interaction, O-GlcNAc glycoproteins in the nucleus and cytoplasm, the roles of sphingolipids and glycosphingolipids in membranes, and transgenic approaches to the analysis of carbohydrate function. Annotation c. Book News, Inc., Portland, OR (booknews.com)3 Stars from Doody